Therapeutic Applications of Natural Products in Biomedicine and Pharmacotherapy
7 affiliations
- 1Department of Medical Laboratory Science, College of Applied and Health Sciences, A’ Sharqiyah University, Ibra 400, Oman
- 2Faculty of Pharmacy, Vidya University, Meerut 250005, UP, India
- 3Noida Institute of Engineering and Technology (Pharmacy Institute), Greater Noida 201306, UP, India
- 4Department of Faculty and Hospital Therapy, Bukhara State Medical Institute, Bukhara 200100, Uzbekistan
- 5School of Allied Health Sciences, Galgotias University, Greater Noida 203201, UP, India
- 6Department of Medical Laboratory Technology, Kalpana Chawala Govt Polytechnic for Women, Ambala City 134003, HR, India
- 7Department of Medical Laboratory Sciences, College of Health Sciences, Gulf Medical University, Ajman 4184, United Arab Emirates
Abstract
Natural products are the fundamentals of drug discovery due to their exceptional structural diversity and biological activity's evolutionary optimization. The review provides a critical and integrative analysis of natural products in pharmaceutical chemistry, highlighting their significance for current biomedicine and pharmacotherapy. The review is organized around a system that connects structure, function, and translation, focusing on structural analysis, scaffold design, and mechanistic understanding in major disease-relevant therapeutic areas. Investigations on representative compounds like paclitaxel, artemisinin, and curcumin are presented to explain the way molecular architecture regulates pharmacological activity, drug selectivity, and clinical performance. The review evaluates significant medicinal chemistry strategies, including semisynthetic modification, prodrug design, and scaffold optimization, and their crucial roles in enhancing potency, pharmacokinetics, and safety. We critically examine the latest advancements in drug delivery technologies, particularly those based on nanotechnology and carrier-free methods, regarding their translational potential and regulatory concern. Current challenges pertaining to pharmacokinetics and ADMET properties, as well as the standardization of analysis, are also examined, emphasizing their impact on reproducibility in research. Researchers investigate the role and limitations of emerging fields such as genome mining, synthetic biology, and network pharmacology in enhancing discovery pipelines. Thus, this review integrates chemical, pharmacological, and translational approaches and suggests an effective strategy to overcome challenges in the development of natural products as the next generation of precision medicine therapeutic agents.
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BibTeX
@article{sah2026therapeutic,
title = {{Therapeutic Applications of Natural Products in Biomedicine and Pharmacotherapy}},
author = {Ashok Kumar Sah and Sakshi Patel and Dr.R .Pranesh Kumar and Prem Shankar Mishra and Rakhi Mishra and Абдулхаков Ихтиёр Умарович and Rabab H. Elshaikh and Shagun Agarwal and Ashwani Bhardwaj and Ranjay Kumar Choudhary and Ayman Hussien Alfeel},
journal = {Life},
year = {2026},
month = may,
doi = {10.3390/life16060873},
url = {https://doi.org/10.3390/life16060873},
note = {CC BY},
}
RIS
TY - JOUR
TI - Therapeutic Applications of Natural Products in Biomedicine and Pharmacotherapy
AU - Ashok Kumar Sah
AU - Sakshi Patel
AU - Dr.R .Pranesh Kumar
AU - Prem Shankar Mishra
AU - Rakhi Mishra
AU - Абдулхаков Ихтиёр Умарович
AU - Rabab H. Elshaikh
AU - Shagun Agarwal
AU - Ashwani Bhardwaj
AU - Ranjay Kumar Choudhary
AU - Ayman Hussien Alfeel
PY - 2026
DA - 2026/05/22
JO - Life
DO - 10.3390/life16060873
UR - https://doi.org/10.3390/life16060873
AB - Natural products are the fundamentals of drug discovery due to their exceptional structural diversity and biological activity's evolutionary optimization. The review provides a critical and integrative analysis of natural products in pharmaceutical chemistry, highlighting their significance for current biomedicine and pharmacotherapy. The review is organized around a system that connects structure, function, and translation, focusing on structural analysis, scaffold design, and mechanistic understanding in major disease-relevant therapeutic areas. Investigations on representative compounds like paclitaxel, artemisinin, and curcumin are presented to explain the way molecular architecture regulates pharmacological activity, drug selectivity, and clinical performance. The review evaluates significant medicinal chemistry strategies, including semisynthetic modification, prodrug design, and scaffold optimization, and their crucial roles in enhancing potency, pharmacokinetics, and safety. We critically examine the latest advancements in drug delivery technologies, particularly those based on nanotechnology and carrier-free methods, regarding their translational potential and regulatory concern. Current challenges pertaining to pharmacokinetics and ADMET properties, as well as the standardization of analysis, are also examined, emphasizing their impact on reproducibility in research. Researchers investigate the role and limitations of emerging fields such as genome mining, synthetic biology, and network pharmacology in enhancing discovery pipelines. Thus, this review integrates chemical, pharmacological, and translational approaches and suggests an effective strategy to overcome challenges in the development of natural products as the next generation of precision medicine therapeutic agents.
SN - 2075-1729
ER -