A large, comprehensive labeled MRI dataset of the human lateral ventricle choroid plexus

Abstract

The choroid plexus (ChP) is a highly vascularized structure located in the brain ventricles that plays important roles in multiple central nervous system functions. ChP enlargement has been implicated in many neuropsychiatric conditions such as multiple sclerosis, depression, schizophrenia, and Alzheimer's disease. However, limitation in the accuracy of the current segmentation tools highlight the need for more reliable methods to quantify ChP volume in healthy and clinical human populations. The shape and size of the ChP vary drastically from person to person, and currently there are no large ChP datasets which allow comprehensive training of segmentation models. Here we introduce DataPlex, a collection of 700 structural MRI brain images where the lateral ventricle ChP has been manually labeled and checked by expert human raters. DataPlex is balanced and representative across a wide range of scanning parameters, demographics, and clinical profiles, and subject-level information will be available for each labeled image. DataPlex will be open source to support the creation of reliable segmentation tools for the human lateral ventricle ChP.

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BibTeX RIS

BibTeX

@misc{huang2026large,
  title = {{A large, comprehensive labeled MRI dataset of the human lateral ventricle choroid plexus}},
  author = {L.-Y. Huang and V. Zeng and N. Raymond and B. Stiltner and W. Molho and Y. Cao and D. Bannai and D. Ying and E. Oss and D. P. Dhunna and P. Patel and A. Adesokan and M. Hricay and V. Lyons and N. Tolentino and M. S. Keshavan and P. Fried and M. Jammoul and D. Kuegler and S. Estrada and M. Reuter and P. Lizano},
  howpublished = {bioRxiv},
  year = {2026},
  month = oct,
  doi = {10.64898/2026.10.08.757728},
  url = {https://www.biorxiv.org/content/10.64898/2026.10.08.757728v1},
  note = {CC BY},
}

RIS

TY  - UNPB
TI  - A large, comprehensive labeled MRI dataset of the human lateral ventricle choroid plexus
AU  - L.-Y. Huang
AU  - V. Zeng
AU  - N. Raymond
AU  - B. Stiltner
AU  - W. Molho
AU  - Y. Cao
AU  - D. Bannai
AU  - D. Ying
AU  - E. Oss
AU  - D. P. Dhunna
AU  - P. Patel
AU  - A. Adesokan
AU  - M. Hricay
AU  - V. Lyons
AU  - N. Tolentino
AU  - M. S. Keshavan
AU  - P. Fried
AU  - M. Jammoul
AU  - D. Kuegler
AU  - S. Estrada
AU  - M. Reuter
AU  - P. Lizano
PY  - 2026
DA  - 2026/10/08
PB  - bioRxiv
DO  - 10.64898/2026.10.08.757728
UR  - https://www.biorxiv.org/content/10.64898/2026.10.08.757728v1
AB  - The choroid plexus (ChP) is a highly vascularized structure located in the brain ventricles that plays important roles in multiple central nervous system functions. ChP enlargement has been implicated in many neuropsychiatric conditions such as multiple sclerosis, depression, schizophrenia, and Alzheimer's disease. However, limitation in the accuracy of the current segmentation tools highlight the need for more reliable methods to quantify ChP volume in healthy and clinical human populations. The shape and size of the ChP vary drastically from person to person, and currently there are no large ChP datasets which allow comprehensive training of segmentation models. Here we introduce DataPlex, a collection of 700 structural MRI brain images where the lateral ventricle ChP has been manually labeled and checked by expert human raters. DataPlex is balanced and representative across a wide range of scanning parameters, demographics, and clinical profiles, and subject-level information will be available for each labeled image. DataPlex will be open source to support the creation of reliable segmentation tools for the human lateral ventricle ChP.
ER  -

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