Detection, resection and cure: a systematic review and meta-analysis of 18F-choline PET in primary hyperparathyroidism
Abstract
INTRODUCTION: F-choline (FCH) PET has emerged as a highly performant imaging technique for guiding parathyroidectomy. As cure is the goal of surgery, the main aims of this study were to summarize patient-based sensitivity, positive predictive value (PPV), and cure rate of FCH PET guided surgery in the surgical management of pHPT. EVIDENCE ACQUISITION: We conducted a systematic review and metaanalysis according to the PRISMA Guidelines. A literature search was performed in the PubMed, Web of Science and Cochrane databases, last updated November 2022. Original articles on choline PET in patients with pHPT mentioning patient-based sensitivity, PPV and cure rate were retained. Quality of included studies was assessed using the QUADAS-2 Tool. Patient-based sensitivity, PPV and cure rate were pooled by using a random-effects model. EVIDENCE SYNTHESIS: Twenty-three studies including 1716 patients were included for quantitative assessment. FCH PET showed a pooled patient-based sensitivity of 93.8% (95% CI: 89.8-96.3) and PPV of 97% (95% CI: 92.8-98.8) in patients with pHPT. Parathyroid surgery was performed in 1129 patients. The pooled cure rate of PET-guided surgery was 92.8% (95% CI: 87.4-96.0). Heterogeneity was shown to be moderate for all effect sizes. CONCLUSIONS: FCH PET showed a high patient-based sensitivity, PPV and cure rate of PET guided surgery in patients with pHPT.
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BibTeX
@article{quak2026detection,
title = {{Detection, resection and cure: a systematic review and meta-analysis of 18F-choline PET in primary hyperparathyroidism}},
author = {Elske Quak and Marie Cavarec and Renaud Ciappuccini and Gilles Girault and Roman Rouzier and Justine Lequesne},
journal = {The quarterly journal of nuclear medicine and molecular imaging},
year = {2026},
month = sep,
doi = {10.23736/s1824-4785.23.03512-4},
url = {https://hal.science/hal-05744796v1},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - Detection, resection and cure: a systematic review and meta-analysis of 18F-choline PET in primary hyperparathyroidism
AU - Elske Quak
AU - Marie Cavarec
AU - Renaud Ciappuccini
AU - Gilles Girault
AU - Roman Rouzier
AU - Justine Lequesne
PY - 2026
DA - 2026/09/10
JO - The quarterly journal of nuclear medicine and molecular imaging
DO - 10.23736/s1824-4785.23.03512-4
UR - https://hal.science/hal-05744796v1
AB - INTRODUCTION: F-choline (FCH) PET has emerged as a highly performant imaging technique for guiding parathyroidectomy. As cure is the goal of surgery, the main aims of this study were to summarize patient-based sensitivity, positive predictive value (PPV), and cure rate of FCH PET guided surgery in the surgical management of pHPT. EVIDENCE ACQUISITION: We conducted a systematic review and metaanalysis according to the PRISMA Guidelines. A literature search was performed in the PubMed, Web of Science and Cochrane databases, last updated November 2022. Original articles on choline PET in patients with pHPT mentioning patient-based sensitivity, PPV and cure rate were retained. Quality of included studies was assessed using the QUADAS-2 Tool. Patient-based sensitivity, PPV and cure rate were pooled by using a random-effects model. EVIDENCE SYNTHESIS: Twenty-three studies including 1716 patients were included for quantitative assessment. FCH PET showed a pooled patient-based sensitivity of 93.8% (95% CI: 89.8-96.3) and PPV of 97% (95% CI: 92.8-98.8) in patients with pHPT. Parathyroid surgery was performed in 1129 patients. The pooled cure rate of PET-guided surgery was 92.8% (95% CI: 87.4-96.0). Heterogeneity was shown to be moderate for all effect sizes. CONCLUSIONS: FCH PET showed a high patient-based sensitivity, PPV and cure rate of PET guided surgery in patients with pHPT.
SN - 1824-4785
ER -