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Peer-reviewedCC BY 4.0Molecules

A Collagen-Derived Peptide Fraction CCAP1 from Colla Corii Asini Attenuates UVB-Induced Skin Photoaging via an AMPK-Dependent Nrf2/NF-κB Axis

  • Fen Du1
  • Zhuang Miao2
  • Wanxiu Cao1
  • Yangen Sun1,2
  • Xiaomei Feng1
  • Haibin Liu2
  • Changwei Wang1
  • Jie Cheng2
  • Xueyuan Fu1
  • Dongwei Wang2
  • Bafang Li1
  • Xiaobo Duan2
1 more authors
  • Chuyi Liu1
  1. 1Marine Biomedical Research Institute of Qingdao, Ocean University of China, Qingdao 266100, China
  2. 2Shandong Key Laboratory of Gelatine Medicines Research and Development, Dong’e Ejiao Co., Ltd., Liaocheng 252200, China
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Abstract

Chronic UVB exposure drives extrinsic skin aging through oxidative stress, inflammation, and collagen degradation. Although oral collagen peptides are promising photoprotective agents, most preparations lack defined composition and mechanistic validation. Here, we characterized CCAP1, a type I collagen-derived oligopeptide fraction (~1.7 kDa; 94.69% collagen-related components) prepared from Colla Corii Asini by dual-enzymatic hydrolysis and membrane fractionation. In UVB-irradiated mice, oral CCAP1 (100 and 200 mg/kg/d, 28 days) markedly alleviated UVB-induced epidermal hyperplasia, restored skin hydration and dermal collagen types I/III/IV, and suppressed MMP1. Untargeted skin metabolomics nominated AMPK signaling as the central node; Western blotting confirmed that CCAP1 activated the AMPK/Nrf2 axis while suppressing NF-κB phosphorylation, with elevated SOD activity and reduced MDA content. In UVB-injured HaCaT keratinocytes, CCAP1 restored cell viability and reduced intracellular ROS, and both effects were abolished by the AMPK inhibitor Compound C, establishing AMPK as a functionally required mediator. Collectively, CCAP1 is a composition-defined, orally bioavailable collagen peptide fraction that attenuates UVB-induced photoaging via an AMPK-dependent Nrf2/NF-κB regulatory program.

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Cite

BibTeXRIS
BibTeX
@article{du2026collagenderived,
  title = {{A Collagen-Derived Peptide Fraction CCAP1 from Colla Corii Asini Attenuates UVB-Induced Skin Photoaging via an AMPK-Dependent Nrf2/NF-κB Axis}},
  author = {Fen Du and Zhuang Miao and Wanxiu Cao and Yangen Sun and Xiaomei Feng and Haibin Liu and Changwei Wang and Jie Cheng and Xueyuan Fu and Dongwei Wang and Bafang Li and Xiaobo Duan and Chuyi Liu},
  journal = {Molecules},
  year = {2026},
  month = nov,
  doi = {10.3390/molecules31213964},
  url = {https://www.mdpi.com/1420-3049/31/21/3964},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - A Collagen-Derived Peptide Fraction CCAP1 from Colla Corii Asini Attenuates UVB-Induced Skin Photoaging via an AMPK-Dependent Nrf2/NF-κB Axis
AU  - Fen Du
AU  - Zhuang Miao
AU  - Wanxiu Cao
AU  - Yangen Sun
AU  - Xiaomei Feng
AU  - Haibin Liu
AU  - Changwei Wang
AU  - Jie Cheng
AU  - Xueyuan Fu
AU  - Dongwei Wang
AU  - Bafang Li
AU  - Xiaobo Duan
AU  - Chuyi Liu
PY  - 2026
DA  - 2026/11/03
JO  - Molecules
DO  - 10.3390/molecules31213964
UR  - https://www.mdpi.com/1420-3049/31/21/3964
AB  - Chronic UVB exposure drives extrinsic skin aging through oxidative stress, inflammation, and collagen degradation. Although oral collagen peptides are promising photoprotective agents, most preparations lack defined composition and mechanistic validation. Here, we characterized CCAP1, a type I collagen-derived oligopeptide fraction (~1.7 kDa; 94.69% collagen-related components) prepared from Colla Corii Asini by dual-enzymatic hydrolysis and membrane fractionation. In UVB-irradiated mice, oral CCAP1 (100 and 200 mg/kg/d, 28 days) markedly alleviated UVB-induced epidermal hyperplasia, restored skin hydration and dermal collagen types I/III/IV, and suppressed MMP1. Untargeted skin metabolomics nominated AMPK signaling as the central node; Western blotting confirmed that CCAP1 activated the AMPK/Nrf2 axis while suppressing NF-κB phosphorylation, with elevated SOD activity and reduced MDA content. In UVB-injured HaCaT keratinocytes, CCAP1 restored cell viability and reduced intracellular ROS, and both effects were abolished by the AMPK inhibitor Compound C, establishing AMPK as a functionally required mediator. Collectively, CCAP1 is a composition-defined, orally bioavailable collagen peptide fraction that attenuates UVB-induced photoaging via an AMPK-dependent Nrf2/NF-κB regulatory program.
SN  - 1420-3049
ER  -