Accelerated Preoperative Wound Bed Preparation Using Negative Pressure Wound Therapy With Instillation and Dwell Time: A Comparison With Conventional Negative Pressure Wound Therapy in Necrotic Wounds.
- 1Department of Plastic Surgery, Kyorin University School of Medicine, Mitaka, Tokyo, Japan.
Abstract
Negative pressure wound therapy with instillation and dwell time (NPWTi-d) and conventional NPWT are established treatments for complex wounds, yet direct comparative evidence remains limited. This retrospective observational study evaluated the clinical effectiveness of NPWTi-d for hard-to-heal necrotic wounds using standardized parameters from our previous research. We included 116 patients (50 NPWTi-d; 66 conventional NPWT). The primary endpoint was the time from therapy initiation to achieving a 'reference wound' suitable for definitive closure, defined in accordance with clinical trial guidance from the Japanese Pharmaceuticals and Medical Devices Agency (PMDA). The NPWTi-d group achieved reference wound status in a median of 14 days versus 22 days for the conventional NPWT group-a statistically significant 8-day reduction. Furthermore, whereas conventional NPWT typically requires a prolonged debridement phase prior to application, NPWTi-d can be initiated earlier, even in the presence of residual necrotic tissue. Ultimately, NPWTi-d provides a synergistic clinical advantage by both shortening active treatment duration and bypassing pre-initiation delays, enabling clinicians to achieve surgical readiness significantly faster than with standard modalities.
Related
- Comparison of piezosurgery vs. conventional bone chisel for extraction of impacted mandibular third molars with root–canal intimacy: a retrospective cohort study with CBCT-based preoperative planning
- Comparison of Hockey-Stick and Conventional Linear Ultrasound Transducers for Detection of Non-Displaced Dentoalveolar Fractures: An Ex Vivo Paired Comparative Study
- Preoperative staging of gastric cancer: a prospective comparison of gastric filling ultrasonography and enhanced CT with implications for surgical decision-making
- Perceived factors shaping preoperative self-preparation among older patients undergoing total knee arthroplasty: a qualitative study
- Magnetic Resonance Imaging in the Preoperative Assessment of Anal Fistula: Diagnostic Performance and Comparison of the St. James and Garg Classifications
BibTeX
@article{ohura2026accelerated,
title = {{Accelerated Preoperative Wound Bed Preparation Using Negative Pressure Wound Therapy With Instillation and Dwell Time: A Comparison With Conventional Negative Pressure Wound Therapy in Necrotic Wounds.}},
author = {Norihiko Ohura and Daisuke Nakayama and Mikio Kinoshita and Tomohide Shiraishi and Yuki Morishige and Shungo Murai and Mine Ozaki},
journal = {International wound journal},
year = {2026},
month = oct,
doi = {10.1111/iwj.71079},
url = {https://europepmc.org/article/MED/42952033},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Accelerated Preoperative Wound Bed Preparation Using Negative Pressure Wound Therapy With Instillation and Dwell Time: A Comparison With Conventional Negative Pressure Wound Therapy in Necrotic Wounds.
AU - Norihiko Ohura
AU - Daisuke Nakayama
AU - Mikio Kinoshita
AU - Tomohide Shiraishi
AU - Yuki Morishige
AU - Shungo Murai
AU - Mine Ozaki
PY - 2026
DA - 2026/10/28
JO - International wound journal
DO - 10.1111/iwj.71079
UR - https://europepmc.org/article/MED/42952033
AB - Negative pressure wound therapy with instillation and dwell time (NPWTi-d) and conventional NPWT are established treatments for complex wounds, yet direct comparative evidence remains limited. This retrospective observational study evaluated the clinical effectiveness of NPWTi-d for hard-to-heal necrotic wounds using standardized parameters from our previous research. We included 116 patients (50 NPWTi-d; 66 conventional NPWT). The primary endpoint was the time from therapy initiation to achieving a 'reference wound' suitable for definitive closure, defined in accordance with clinical trial guidance from the Japanese Pharmaceuticals and Medical Devices Agency (PMDA). The NPWTi-d group achieved reference wound status in a median of 14 days versus 22 days for the conventional NPWT group-a statistically significant 8-day reduction. Furthermore, whereas conventional NPWT typically requires a prolonged debridement phase prior to application, NPWTi-d can be initiated earlier, even in the presence of residual necrotic tissue. Ultimately, NPWTi-d provides a synergistic clinical advantage by both shortening active treatment duration and bypassing pre-initiation delays, enabling clinicians to achieve surgical readiness significantly faster than with standard modalities.
SN - 1742-4801
SN - 1742-481X
ER -