Phenotyping of Arrhythmia-induced Cardiomyopathy: From Bench to Bedside and Back
4 affiliations
- 1Medical Clinic I, Cardiology and Angiology, University Hospital of Giessen and Marburg, Giessen, Germany
- 2Institute for Experimental and Translational Cardiology, Justus-Liebig-Universität Giessen, Giessen, Germany
- 3Department of Cardiology at Kerckhoff Heart and Lung Center, Bad Nauheim, Germany
- 4Excellence Cluster Cardiopulmonary Institute (CPI), Giessen, Germany
Abstract
Purpose of Review: Arrhythmia-induced cardiomyopathy (AIC) is an increasingly recognized and potentially reversible cause or modifier of heart failure. This review summarizes experimental and clinical evidence with a focus on atrial fibrillation (AFib)-induced left ventricular systolic dysfunction.
Recent Findings: Recent studies demonstrate that AIC extends beyond tachycardia alone and involves rhythm irregularity, loss of atrioventricular synchrony, altered calcium handling, oxidative stress, mitochondrial dysfunction and substrate vulnerability. Clinical trials demonstrate the superiority of rhythm control therapy by catheter ablation in patients with AFib and heart failure. Emerging data illustrate the importance of phenotyping of AIC according to myocardial substrate and individual ventricular response to AFib.
Summary: AIC should be considered as a heterogeneous spectrum. Refined phenotyping may improve prediction of recovery and guide specific and individual therapy.
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BibTeX
@article{kortl2026phenotyping,
title = {{Phenotyping of Arrhythmia-induced Cardiomyopathy: From Bench to Bedside and Back}},
author = {Thomas Körtl and Johannes Ruppert and Samuel Sossalla},
journal = {Current Heart Failure Reports},
year = {2026},
month = oct,
doi = {10.1007/s11897-026-00788-3},
url = {https://doi.org/10.1007/s11897-026-00788-3},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Phenotyping of Arrhythmia-induced Cardiomyopathy: From Bench to Bedside and Back
AU - Thomas Körtl
AU - Johannes Ruppert
AU - Samuel Sossalla
PY - 2026
DA - 2026/10/27
JO - Current Heart Failure Reports
DO - 10.1007/s11897-026-00788-3
UR - https://doi.org/10.1007/s11897-026-00788-3
AB - Purpose of Review: Arrhythmia-induced cardiomyopathy (AIC) is an increasingly recognized and potentially reversible cause or modifier of heart failure. This review summarizes experimental and clinical evidence with a focus on atrial fibrillation (AFib)-induced left ventricular systolic dysfunction. Recent Findings: Recent studies demonstrate that AIC extends beyond tachycardia alone and involves rhythm irregularity, loss of atrioventricular synchrony, altered calcium handling, oxidative stress, mitochondrial dysfunction and substrate vulnerability. Clinical trials demonstrate the superiority of rhythm control therapy by catheter ablation in patients with AFib and heart failure. Emerging data illustrate the importance of phenotyping of AIC according to myocardial substrate and individual ventricular response to AFib. Summary: AIC should be considered as a heterogeneous spectrum. Refined phenotyping may improve prediction of recovery and guide specific and individual therapy.
SN - 1546-9530
SN - 1546-9549
ER -