Event-related potential signatures of auditory predictive processing in first-episode psychosis: a passive pattern-based study
- 1Universidad de Sevilla
Abstract
BackgroundPredictive-processing accounts propose altered prediction-error signaling in psychosis. However, event-related potential (ERP) findings in first-episode psychosis (FEP) are inconsistent and focused predominantly on mismatch negativity (MMN). Examining anticipatory and later post-stimulus ERP responses alongside MMN within a single passive paradigm may broaden the assessment of predictive processing in FEP.
Methods34 participants with non-affective FEP and 34 healthy controls (HC) underwent EEG during a passive auditory pattern-based paradigm. Mean amplitudes of contingent negative variation (CNV), MMN, and post-imperative negative variation (PINV) were quantified at five frontocentral electrodes. Exploratory analyses examined N1 and P2 mean amplitudes. Mixed models tested group, electrode, and group-by-electrode effects adjusting for age, sex and years of education. Regressions examined ERP associations with psychotic-like experiences, neurocognition, and social cognition across groups, and with symptoms, functioning, and antipsychotic dose within FEP.
ResultsFEP participants reported more psychotic-like experiences and showed poorer global and social cognition than HC (all p-FDR [≤].042). Standardized adjusted FEP-HC differences at FCz were nonsignificant for CNV ({beta} = -0.46), MMN ({beta} = -0.30), and PINV ({beta} = -0.10; all p-FDR [≥].265). Exploratory analyses identified lower P2 amplitude in FEP at FCz ({beta} = -0.73; p-FDR =.019) and in the averaged frontocentral ROI ({beta} = -0.64; p-FDR =.027). No ERP-phenotype associations survived FDR correction.
ConclusionsDespite phenotypic differences between FEP and HC, no significant differences emerged in the primary ERP indices of predictive processing examined. The exploratory P2 finding and its possible relationship to predictive processing and frontal dysfunction in FEP warrant further investigation.
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BibTeX
@misc{munozcaracuel2026eventrelated,
title = {{Event-related potential signatures of auditory predictive processing in first-episode psychosis: a passive pattern-based study}},
author = {M. Munoz-Caracuel and V. Munoz and B. Angulo and F. J. Ruiz-Martinez and S. Perona-Garcelan and M. I. Garrido and R. Romero-Garcia and A. J. Vazquez Morejon and B. Crespo-Facorro and C. M. Gomez},
howpublished = {medRxiv},
year = {2026},
month = oct,
doi = {10.64898/2026.10.19.26365874},
url = {https://www.medrxiv.org/content/10.64898/2026.10.19.26365874v1},
note = {CC BY-NC-ND},
}
RIS
TY - UNPB
TI - Event-related potential signatures of auditory predictive processing in first-episode psychosis: a passive pattern-based study
AU - M. Munoz-Caracuel
AU - V. Munoz
AU - B. Angulo
AU - F. J. Ruiz-Martinez
AU - S. Perona-Garcelan
AU - M. I. Garrido
AU - R. Romero-Garcia
AU - A. J. Vazquez Morejon
AU - B. Crespo-Facorro
AU - C. M. Gomez
PY - 2026
DA - 2026/10/19
PB - medRxiv
DO - 10.64898/2026.10.19.26365874
UR - https://www.medrxiv.org/content/10.64898/2026.10.19.26365874v1
AB - BackgroundPredictive-processing accounts propose altered prediction-error signaling in psychosis. However, event-related potential (ERP) findings in first-episode psychosis (FEP) are inconsistent and focused predominantly on mismatch negativity (MMN). Examining anticipatory and later post-stimulus ERP responses alongside MMN within a single passive paradigm may broaden the assessment of predictive processing in FEP. Methods34 participants with non-affective FEP and 34 healthy controls (HC) underwent EEG during a passive auditory pattern-based paradigm. Mean amplitudes of contingent negative variation (CNV), MMN, and post-imperative negative variation (PINV) were quantified at five frontocentral electrodes. Exploratory analyses examined N1 and P2 mean amplitudes. Mixed models tested group, electrode, and group-by-electrode effects adjusting for age, sex and years of education. Regressions examined ERP associations with psychotic-like experiences, neurocognition, and social cognition across groups, and with symptoms, functioning, and antipsychotic dose within FEP. ResultsFEP participants reported more psychotic-like experiences and showed poorer global and social cognition than HC (all p-FDR [≤].042). Standardized adjusted FEP-HC differences at FCz were nonsignificant for CNV ({beta} = -0.46), MMN ({beta} = -0.30), and PINV ({beta} = -0.10; all p-FDR [≥].265). Exploratory analyses identified lower P2 amplitude in FEP at FCz ({beta} = -0.73; p-FDR =.019) and in the averaged frontocentral ROI ({beta} = -0.64; p-FDR =.027). No ERP-phenotype associations survived FDR correction. ConclusionsDespite phenotypic differences between FEP and HC, no significant differences emerged in the primary ERP indices of predictive processing examined. The exploratory P2 finding and its possible relationship to predictive processing and frontal dysfunction in FEP warrant further investigation.
ER -