Deep Fascia Plane Dissection and Mattox Maneuver for Lymphadenectomy in Pancreatic Body-Tail Cancer: SEER-Based Evidence, Anatomical Rationale, and Quantitative Modeling
- 1Department of General Surgery, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Abstract
IntroductionThe optimal examined lymph node (ELN) count after resection for pancreatic body/tail ductal adenocarcinoma (PDAC) is debated. We combined SEER-based survival modelling with a hypothesis-generating theoretical framework to identify ELN thresholds and how surgical approach influences attainability.
MethodSEER (2000-2022) resected pancreatic body/tail PDAC cases were analysed (n=5 107). Thresholds were identified by log-rank grid search and segmented Cox changepoint analysis; multivariable Cox and overlap- and inverse-probability-weighted restricted mean survival time (RMST) analyses were performed.
ResultsAmong 5 107 patients, ELN=12 was the optimal cut-point and ELN=21 the changepoint (95% CI 6.0-35.0). Each 5-node increase in ELN was associated with HR 0.964 (95% CI 0.949-0.980); overlap-weighted 60-month RMST gain for ELN>=21 was 2.60 months (95% CI 1.30-3.90). Distribution-derived (model-estimated) ELN>=21 attainment was 16.5% (DP), 40.0% (RAMPS), and 82.7% (n=9, deep retroperitoneal/left-posterior). Theoretical modeling estimated model ELN of 16, 21, and 27 for DP, RAMPS, and Mattox, with Monte Carlo P(ELN>=21) of 5.5%, 34.8%, and 92.9%. Quality-weighted risk reduction was 22.9% for Mattox versus 8.4% for RAMPS.
ConclusionELN>=12 is a minimum quality benchmark, and approximately 21 a potential higher-yield target. Standard DP carries an accessibility gap for the higher target. Theoretical modeling suggests the Mattox maneuver could bridge this gap, but this remains hypothesis-generating and requires prospective validation.
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BibTeX
@misc{ye2026deep,
title = {{Deep Fascia Plane Dissection and Mattox Maneuver for Lymphadenectomy in Pancreatic Body-Tail Cancer: SEER-Based Evidence, Anatomical Rationale, and Quantitative Modeling}},
author = {X. Ye and Y. Wang and W. Yang and J. Wu and J. Fang and G. M. Kihaga and Y. Zheng},
howpublished = {medRxiv},
year = {2026},
month = jul,
doi = {10.64898/2026.07.06.26357392},
url = {https://www.medrxiv.org/content/10.64898/2026.07.06.26357392v4},
note = {CC BY},
}
RIS
TY - UNPB
TI - Deep Fascia Plane Dissection and Mattox Maneuver for Lymphadenectomy in Pancreatic Body-Tail Cancer: SEER-Based Evidence, Anatomical Rationale, and Quantitative Modeling
AU - X. Ye
AU - Y. Wang
AU - W. Yang
AU - J. Wu
AU - J. Fang
AU - G. M. Kihaga
AU - Y. Zheng
PY - 2026
DA - 2026/07/06
PB - medRxiv
DO - 10.64898/2026.07.06.26357392
UR - https://www.medrxiv.org/content/10.64898/2026.07.06.26357392v4
AB - IntroductionThe optimal examined lymph node (ELN) count after resection for pancreatic body/tail ductal adenocarcinoma (PDAC) is debated. We combined SEER-based survival modelling with a hypothesis-generating theoretical framework to identify ELN thresholds and how surgical approach influences attainability. MethodSEER (2000-2022) resected pancreatic body/tail PDAC cases were analysed (n=5 107). Thresholds were identified by log-rank grid search and segmented Cox changepoint analysis; multivariable Cox and overlap- and inverse-probability-weighted restricted mean survival time (RMST) analyses were performed. ResultsAmong 5 107 patients, ELN=12 was the optimal cut-point and ELN=21 the changepoint (95% CI 6.0-35.0). Each 5-node increase in ELN was associated with HR 0.964 (95% CI 0.949-0.980); overlap-weighted 60-month RMST gain for ELN>=21 was 2.60 months (95% CI 1.30-3.90). Distribution-derived (model-estimated) ELN>=21 attainment was 16.5% (DP), 40.0% (RAMPS), and 82.7% (n=9, deep retroperitoneal/left-posterior). Theoretical modeling estimated model ELN of 16, 21, and 27 for DP, RAMPS, and Mattox, with Monte Carlo P(ELN>=21) of 5.5%, 34.8%, and 92.9%. Quality-weighted risk reduction was 22.9% for Mattox versus 8.4% for RAMPS. ConclusionELN>=12 is a minimum quality benchmark, and approximately 21 a potential higher-yield target. Standard DP carries an accessibility gap for the higher target. Theoretical modeling suggests the Mattox maneuver could bridge this gap, but this remains hypothesis-generating and requires prospective validation.
ER -