Dorsal striatal astrocytes link dopamine to slow behavioral dynamics

Abstract

Humans and other animals repeatedly pause from their goal-directed behavior by taking breaks. How rapid neuromodulatory signals help organize these daily engagement-disengagement cycles has remained unclear, as most studies have concentrated on in-task behavior. Here we added study of the breaks. We made simultaneous recordings of striatal dopamine release and astrocytic calcium activity as mice performed a decision-making task and took sporadic breaks. Dopamine release more strongly represented task events, whereas astrocytic calcium more strongly tracked disengagement during breaks and behavioral state cycles. Dopamine activity led to astrocytic activity, protracted adenosine signaling and dopamine depression. Blocking astrocytic calcium signals impaired engagement and rule-based learning. Astrocytes thus represent an essential aspect of the temporal organization of voluntary behavior, spanning the full engagement-disengagement cycles of daily life.

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BibTeX

@misc{lazaridis2026dorsal,
  title = {{Dorsal striatal astrocytes link dopamine to slow behavioral dynamics}},
  author = {Iakovos Lazaridis and Emily Hueske and Gun Ahn and Wonchang Choi and Kojiro Hirokane and Sabrina Drammis and Ann M. Graybiel},
  howpublished = {bioRxiv},
  year = {2026},
  month = oct,
  doi = {10.1101/2024.12.01.626240},
  url = {https://doi.org/10.1101/2024.12.01.626240},
  note = {CC BY 4.0},
}

RIS

TY  - UNPB
TI  - Dorsal striatal astrocytes link dopamine to slow behavioral dynamics
AU  - Iakovos Lazaridis
AU  - Emily Hueske
AU  - Gun Ahn
AU  - Wonchang Choi
AU  - Kojiro Hirokane
AU  - Sabrina Drammis
AU  - Ann M. Graybiel
PY  - 2026
DA  - 2026/10/14
PB  - bioRxiv
DO  - 10.1101/2024.12.01.626240
UR  - https://doi.org/10.1101/2024.12.01.626240
AB  - Humans and other animals repeatedly pause from their goal-directed behavior by taking breaks. How rapid neuromodulatory signals help organize these daily engagement-disengagement cycles has remained unclear, as most studies have concentrated on in-task behavior. Here we added study of the breaks. We made simultaneous recordings of striatal dopamine release and astrocytic calcium activity as mice performed a decision-making task and took sporadic breaks. Dopamine release more strongly represented task events, whereas astrocytic calcium more strongly tracked disengagement during breaks and behavioral state cycles. Dopamine activity led to astrocytic activity, protracted adenosine signaling and dopamine depression. Blocking astrocytic calcium signals impaired engagement and rule-based learning. Astrocytes thus represent an essential aspect of the temporal organization of voluntary behavior, spanning the full engagement-disengagement cycles of daily life.
SN  - 2692-8205
ER  -

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