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Peer-reviewedCC BYVeterinary research communications

Concurrent fibrinogen Aα-chain amyloidosis and AA amyloidosis in a Humboldt penguin (Spheniscus humboldti).

  • Susumu Iwaide1,2,3
  • Natsumi Kobayashi4
  • Mako Ikudome4
  • Shiho Takezawa5
  • Yoshiyuki Itoh6
  • Tomoyuki Shibahara7,8
  • Keisuke Kawase9
  • Tomoaki Murakami4
9 affiliations
  1. 1Research Unit of Innovative One Medicine, Advanced Research Center for One Welfare, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai- cho, Fuchu, Tokyo, Japan. [email protected].
  2. 2Laboratory of Veterinary Toxicology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Fuchu, Tokyo, Japan. [email protected].
  3. 3National Institute of Animal Health, National Agriculture and Food Research Organization, 3-1-5 Kannondai, Tsukuba, Ibaraki, Japan. [email protected].
  4. 4Laboratory of Veterinary Toxicology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Fuchu, Tokyo, Japan.
  5. 5Ibaraki Prefectural Kenpoku Livestock Hygiene Service Center, 966-1 Nakagachi-cho, Mito, Ibaraki, Japan.
  6. 6Smart-Core-Facility Promotion Organization, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo, Japan.
  7. 7National Institute of Animal Health, National Agriculture and Food Research Organization, 3-1-5 Kannondai, Tsukuba, Ibaraki, Japan.
  8. 8Department of Veterinary Immunology, Graduate School of Veterinary Medical Sciences, Osaka Metropolitan University, 1-58 Rinku- oraikita, Izumisano, Osaka, Japan.
  9. 9Hitachi Kamine Zoo, 5-2-22, Miyata-cho, Hitachi, Ibaraki, Japan.
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Abstract

Amyloidosis is a disease characterized by the deposition of abnormally folded proteins as amyloid fibrils in tissues and occurs in various mammals and birds. In some cases, amyloids derived from two different precursor proteins may coexist in the same individual, a condition known as double amyloidosis. Amyloid A (AA) amyloidosis is known to occur frequently in birds; however, little is known about other types of amyloidosis. In the present study, we report a case of amyloidosis in a Humboldt penguin involving two distinct types of amyloids. Histopathological examination, transmission electron microscopy, mass spectrometry-based proteomic analysis, and immunohistochemistry revealed the concurrent occurrence of fibrinogen Aα-chain (FibA) amyloidosis and AA amyloidosis. FibA-derived and AA amyloid deposits exhibited distinct nodular and diffuse morphologies, respectively, suggesting that their deposition patterns may provide a morphological clue for distinguishing between the two types of amyloids. To our knowledge, this is the first case of FibA amyloidosis in a penguin and the first report of the concurrent occurrence of two distinct types of systemic amyloidosis in a bird.

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Cite

BibTeXRIS
BibTeX
@article{iwaide2026concurrent,
  title = {{Concurrent fibrinogen Aα-chain amyloidosis and AA amyloidosis in a Humboldt penguin (Spheniscus humboldti).}},
  author = {Susumu Iwaide and Natsumi Kobayashi and Mako Ikudome and Shiho Takezawa and Yoshiyuki Itoh and Tomoyuki Shibahara and Keisuke Kawase and Tomoaki Murakami},
  journal = {Veterinary research communications},
  year = {2026},
  month = oct,
  doi = {10.1007/s11259-026-11572-y},
  url = {https://europepmc.org/article/MED/42858211},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Concurrent fibrinogen Aα-chain amyloidosis and AA amyloidosis in a Humboldt penguin (Spheniscus humboldti).
AU  - Susumu Iwaide
AU  - Natsumi Kobayashi
AU  - Mako Ikudome
AU  - Shiho Takezawa
AU  - Yoshiyuki Itoh
AU  - Tomoyuki Shibahara
AU  - Keisuke Kawase
AU  - Tomoaki Murakami
PY  - 2026
DA  - 2026/10/10
JO  - Veterinary research communications
DO  - 10.1007/s11259-026-11572-y
UR  - https://europepmc.org/article/MED/42858211
AB  - Amyloidosis is a disease characterized by the deposition of abnormally folded proteins as amyloid fibrils in tissues and occurs in various mammals and birds. In some cases, amyloids derived from two different precursor proteins may coexist in the same individual, a condition known as double amyloidosis. Amyloid A (AA) amyloidosis is known to occur frequently in birds; however, little is known about other types of amyloidosis. In the present study, we report a case of amyloidosis in a Humboldt penguin involving two distinct types of amyloids. Histopathological examination, transmission electron microscopy, mass spectrometry-based proteomic analysis, and immunohistochemistry revealed the concurrent occurrence of fibrinogen Aα-chain (FibA) amyloidosis and AA amyloidosis. FibA-derived and AA amyloid deposits exhibited distinct nodular and diffuse morphologies, respectively, suggesting that their deposition patterns may provide a morphological clue for distinguishing between the two types of amyloids. To our knowledge, this is the first case of FibA amyloidosis in a penguin and the first report of the concurrent occurrence of two distinct types of systemic amyloidosis in a bird.
SN  - 0165-7380
SN  - 1573-7446
ER  -