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Peer-reviewedCC BY-NC-NDNature Neuroscience

Cross-region neuron co-firing mediated by ripple oscillations supports distributed working memory representations

  • Ilya A. Verzhbinsky1,2,3
  • Jonathan Daume4,5
  • Sophia Cheng4,5
  • Ueli Rutishauser6,7,4,8,9
  • Eric Halgren10,11
11 affiliations
  1. 1Medical Scientist Training Program, University of California San Diego, La Jolla, CA, USA. [email protected]
  2. 2Neurosciences Graduate Program, University of California San Diego, La Jolla, CA, USA. [email protected]
  3. 3University of California - San Diego
  4. 4Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA
  5. 5Cedars Sinai Medical Center
  6. 6Center for Neural Science and Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA
  7. 7Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA
  8. 8Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA
  9. 9University of California, San Diego
  10. 10Department of Neurosciences, University of California San Diego, La Jolla, CA, USA. [email protected]
  11. 11Department of Radiology, University of California San Diego, La Jolla, CA, USA. [email protected]
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Abstract

High-frequency (~90-Hz) ripple oscillations may promote integrative processing in mammalian brains. Co-occurrence of ripple oscillations has been associated with enhanced temporal binding of neural activity between nearby human cortical neurons, but whether co-ripple facilitation of neuronal coupling supports cognitive processing or occurs at greater distances remains unclear. Here we analyze intracranial recordings from patients implanted with microwire electrodes in the hippocampus, amygdala, ventromedial prefrontal cortex, anterior cingulate cortex and pre-supplementary motor area, bilaterally, during a working memory task. We demonstrate that ripple rates increase in all recorded regions during encoding, maintenance and retrieval. Co-occurrence of ripples increases between brain regions, associated with ~30% increases in cross-region co-firing, without decrement over distances up to 220 mm. Cross-regional co-rippling and associated co-firing scale with memory load during maintenance and retrieval. During retrieval, co-ripples promote reinstatement of stimulus-specific, long-distance co-firing patterns observed during encoding, especially during rapid recognition. Co-occurring ripple oscillations thus coordinate long-range, stimulus-specific neural co-firing supporting distributed representations during human cognition.

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Cite

BibTeXRIS
BibTeX
@article{verzhbinsky2026crossregion,
  title = {{Cross-region neuron co-firing mediated by ripple oscillations supports distributed working memory representations}},
  author = {Ilya A. Verzhbinsky and Jonathan Daume and Sophia Cheng and Ueli Rutishauser and Eric Halgren},
  journal = {Nature Neuroscience},
  year = {2026},
  month = aug,
  doi = {10.1038/s41593-026-02403-z},
  url = {https://doi.org/10.1038/s41593-026-02403-z},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Cross-region neuron co-firing mediated by ripple oscillations supports distributed working memory representations
AU  - Ilya A. Verzhbinsky
AU  - Jonathan Daume
AU  - Sophia Cheng
AU  - Ueli Rutishauser
AU  - Eric Halgren
PY  - 2026
DA  - 2026/08/12
JO  - Nature Neuroscience
DO  - 10.1038/s41593-026-02403-z
UR  - https://doi.org/10.1038/s41593-026-02403-z
AB  - High-frequency (~90-Hz) ripple oscillations may promote integrative processing in mammalian brains. Co-occurrence of ripple oscillations has been associated with enhanced temporal binding of neural activity between nearby human cortical neurons, but whether co-ripple facilitation of neuronal coupling supports cognitive processing or occurs at greater distances remains unclear. Here we analyze intracranial recordings from patients implanted with microwire electrodes in the hippocampus, amygdala, ventromedial prefrontal cortex, anterior cingulate cortex and pre-supplementary motor area, bilaterally, during a working memory task. We demonstrate that ripple rates increase in all recorded regions during encoding, maintenance and retrieval. Co-occurrence of ripples increases between brain regions, associated with ~30% increases in cross-region co-firing, without decrement over distances up to 220 mm. Cross-regional co-rippling and associated co-firing scale with memory load during maintenance and retrieval. During retrieval, co-ripples promote reinstatement of stimulus-specific, long-distance co-firing patterns observed during encoding, especially during rapid recognition. Co-occurring ripple oscillations thus coordinate long-range, stimulus-specific neural co-firing supporting distributed representations during human cognition.
SN  - 1097-6256
SN  - 1546-1726
ER  -