Electrochemical Assessment of the Interfacial Response of Unfractionated Bovine Heparin by Post-Processed Chronoamperometry
- 1Federal University of Rio de Janeiro , , , ,
Abstract
Unfractionated bovine heparin (UFH-bov) is a highly sulfated and polydisperse glycosaminoglycan whose interfacial behavior can influence electrochemical mass transport. In this study, chronoamperometric current–time transients obtained for UFH-bov-containing solutions were numerically integrated to generate charge–time profiles and evaluate the concentration-dependent electrochemical response. The corresponding plots of accumulated charge as a function of the square root of time exhibited approximately linear regions within selected analysis intervals. However, UFH-bov is not directly electroactive under the experimental conditions employed and does not undergo a defined stoichiometric electron-transfer reaction. Consequently, the measured charge cannot be quantitatively related to molecular UFH-bov flux through the classical Cottrell–Anson formalism, and the experimental slopes were not converted into molecular diffusion coefficients. Instead, the slope of the selected Qt versus t1/2 region is interpreted only as an operational descriptor of the UFH-bov-dependent electrochemical response. The observed concentration dependence is consistent with interfacial phenomena, including adsorption, partial electrode blocking, and modulation of background electrochemical processes. This revised interpretation provides a conservative framework for describing square-root-of-time-dependent electrochemical behavior in the presence of a non-directly electroactive sulfated polysaccharide without assigning an unsupported molecular diffusion coefficient.
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BibTeX
@article{coelho2026electrochemical,
title = {{Electrochemical Assessment of the Interfacial Response of Unfractionated Bovine Heparin by Post-Processed Chronoamperometry}},
author = {Gabriel Ferreira Coelho and Leonardo Paes Cinelli and Nelilma Correia Romeiro and Rodrigo de Siqueira Melo},
journal = {ACS Omega},
year = {2026},
month = oct,
doi = {10.1021/acsomega.6c07879},
url = {https://pubs.acs.org/acsodf/article/11/41/63707/5444838/Electrochemical-Assessment-of-the-Interfacial},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Electrochemical Assessment of the Interfacial Response of Unfractionated Bovine Heparin by Post-Processed Chronoamperometry
AU - Gabriel Ferreira Coelho
AU - Leonardo Paes Cinelli
AU - Nelilma Correia Romeiro
AU - Rodrigo de Siqueira Melo
PY - 2026
DA - 2026/10/05
JO - ACS Omega
DO - 10.1021/acsomega.6c07879
UR - https://pubs.acs.org/acsodf/article/11/41/63707/5444838/Electrochemical-Assessment-of-the-Interfacial
AB - Unfractionated bovine heparin (UFH-bov) is a highly sulfated and polydisperse glycosaminoglycan whose interfacial behavior can influence electrochemical mass transport. In this study, chronoamperometric current–time transients obtained for UFH-bov-containing solutions were numerically integrated to generate charge–time profiles and evaluate the concentration-dependent electrochemical response. The corresponding plots of accumulated charge as a function of the square root of time exhibited approximately linear regions within selected analysis intervals. However, UFH-bov is not directly electroactive under the experimental conditions employed and does not undergo a defined stoichiometric electron-transfer reaction. Consequently, the measured charge cannot be quantitatively related to molecular UFH-bov flux through the classical Cottrell–Anson formalism, and the experimental slopes were not converted into molecular diffusion coefficients. Instead, the slope of the selected Qt versus t1/2 region is interpreted only as an operational descriptor of the UFH-bov-dependent electrochemical response. The observed concentration dependence is consistent with interfacial phenomena, including adsorption, partial electrode blocking, and modulation of background electrochemical processes. This revised interpretation provides a conservative framework for describing square-root-of-time-dependent electrochemical behavior in the presence of a non-directly electroactive sulfated polysaccharide without assigning an unsupported molecular diffusion coefficient.
SN - 2470-1343
ER -