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Peer-reviewedCC BY-NC-NDOpen forum infectious diseases

Conservative Infection Prevention and Control Practices in a Patient With Confirmed Creutzfeldt-Jakob Disease.

  • Emily L Lear1
  • Kevin E Kleine2
  • Michael A Goulart1
  • Dana L Luciani1
  • Jorge L Verdecia3
  1. 1Department of Infection Prevention and Control, University of Florida Health Jacksonville, Jacksonville, Florida, USA.
  2. 2Division of Neurology, Department of Medicine, University of Florida Health Jacksonville, Jacksonville, Florida, USA.
  3. 3Division of Infectious Diseases, Department of Medicine, University of Florida Health Jacksonville, Jacksonville, Florida, USA.
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Abstract

Creutzfeldt-Jakob disease (CJD) presents unique infection prevention and control (IPC) challenges because prions resist conventional disinfection and sterilization methods, and evidence guiding reusable endoscope reprocessing remains limited. We describe the management of a 61-year-old woman with confirmed sporadic CJD who required percutaneous endoscopic gastrostomy (PEG) tube placement as part of her care plan. Following multidisciplinary risk assessment and consultation of available literature, device manufacturers, and sterile processing, the IPC team recommended an alternative approach to avoid potential prion contamination of reusable endoscopes. Percutaneous endoscopic gastrostomy placement was successfully performed through interventional radiology using single-use instrumentation, and associated medical waste was managed according to institutional policy. This case highlights the importance of early IPC involvement, multidisciplinary collaboration, and proactive risk assessment when evidence and guidelines are insufficient. Alternative procedural approaches may provide practical, conservative strategies to balance patient-centered care with infection prevention priorities, particularly in resource-constrained healthcare settings.

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Cite

BibTeXRIS
BibTeX
@article{lear2026conservative,
  title = {{Conservative Infection Prevention and Control Practices in a Patient With Confirmed Creutzfeldt-Jakob Disease.}},
  author = {Emily L Lear and Kevin E Kleine and Michael A Goulart and Dana L Luciani and Jorge L Verdecia},
  journal = {Open forum infectious diseases},
  year = {2026},
  month = sep,
  doi = {10.1093/ofid/ofag579},
  url = {https://europepmc.org/article/MED/42953071},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Conservative Infection Prevention and Control Practices in a Patient With Confirmed Creutzfeldt-Jakob Disease.
AU  - Emily L Lear
AU  - Kevin E Kleine
AU  - Michael A Goulart
AU  - Dana L Luciani
AU  - Jorge L Verdecia
PY  - 2026
DA  - 2026/09/11
JO  - Open forum infectious diseases
DO  - 10.1093/ofid/ofag579
UR  - https://europepmc.org/article/MED/42953071
AB  - Creutzfeldt-Jakob disease (CJD) presents unique infection prevention and control (IPC) challenges because prions resist conventional disinfection and sterilization methods, and evidence guiding reusable endoscope reprocessing remains limited. We describe the management of a 61-year-old woman with confirmed sporadic CJD who required percutaneous endoscopic gastrostomy (PEG) tube placement as part of her care plan. Following multidisciplinary risk assessment and consultation of available literature, device manufacturers, and sterile processing, the IPC team recommended an alternative approach to avoid potential prion contamination of reusable endoscopes. Percutaneous endoscopic gastrostomy placement was successfully performed through interventional radiology using single-use instrumentation, and associated medical waste was managed according to institutional policy. This case highlights the importance of early IPC involvement, multidisciplinary collaboration, and proactive risk assessment when evidence and guidelines are insufficient. Alternative procedural approaches may provide practical, conservative strategies to balance patient-centered care with infection prevention priorities, particularly in resource-constrained healthcare settings.
SN  - 2328-8957
ER  -