12-week yoga intervention effect on metabolome in Polyendocrine Metabolic Ovarian Syndrome (PMOS): An LC-MS-based study.
- 1All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India.
- 2Translational Health Science and Technology Institute, Faridabad, Haryana, India.
- 3All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India. Electronic address: [email protected].
Abstract
Background
Polyendocrine metabolic ovarian syndrome (PMOS) is a complex, heterogeneous disorder affecting endocrine, reproductive, and metabolic health. It is fundamentally a systemic metabolic defect that, if not addressed in time, can compromise the function of multiple systems, resulting in conditions such as impaired glucose tolerance, insulin resistance, cardiovascular disease, dyslipidemia, fatty liver disease, and type 2 diabetes mellitus. It is a lifestyle disorder with long-term health implications, requiring a holistic approach for management.Methods
This prospective quasi-experimental study involved 60 women (30 diagnosed with PMOS, 30 age and BMI-matched controls). Women with PMOS underwent a 12-week Yoga practice that included physical postures (Asanas), regulated breathing practice (Pranayama), and meditation (Dhyana) under the guidance of a trained therapist. Clinical characteristics and laboratory biochemical data were recorded, followed by an untargeted metabolomics analysis using high-resolution Orbitrap Fusion Tribrid Mass Spectrometer technology to study plasma metabolome changes.Results
Following Yoga intervention, women with PMOS showed significant improvements in hormonal, anthropometric parameters, and lipid profile. The metabolomics analysis showed that post-Yoga intervention, several key metabolites were significantly downregulated, including glucose, fructose, d-ribose, 3-hydroxybutanoate, taurine, and methylmalonate. However, metabolites like succinate and ascorbate were upregulated. Besides, AUC suggests significant metabolic shifts following Yoga intervention.Conclusion
Yoga offers a holistic, integrated mind-body approach to managing the endocrine, metabolic, and reproductive dysfunction in PMOS and lowers the risk of developing long-term comorbidities.
Related
- Time-Restricted Eating as a Dietary Intervention for Polyendocrine Metabolic Ovarian Syndrome (PMOS): Protocol for a Randomized Controlled Trial
- Polyendocrine metabolic ovarian syndrome in adolescents.
- Polyendocrine metabolic ovarian syndrome: a new name to support better treatment.
- Nutritional Management of Polyendocrine Metabolic Ovarian Syndrome: Current Evidence on Dietary Strategies, Supplementation, and Lifestyle Support
- Associations of hirsutism and sexual function with mental health–related quality of life in women with polyendocrine metabolic ovarian syndrome
BibTeX
@article{kumari202612week,
title = {{12-week yoga intervention effect on metabolome in Polyendocrine Metabolic Ovarian Syndrome (PMOS): An LC-MS-based study.}},
author = {Deepika Kumari and Hanuman Prasad Sharma and Yashwant Kumar and Neena Malhotra and Reeta Mahey and Rima Dada},
journal = {Journal of Ayurveda and integrative medicine},
year = {2026},
month = sep,
doi = {10.1016/j.jaim.2026.101395},
url = {https://europepmc.org/article/MED/42868873},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - 12-week yoga intervention effect on metabolome in Polyendocrine Metabolic Ovarian Syndrome (PMOS): An LC-MS-based study.
AU - Deepika Kumari
AU - Hanuman Prasad Sharma
AU - Yashwant Kumar
AU - Neena Malhotra
AU - Reeta Mahey
AU - Rima Dada
PY - 2026
DA - 2026/09/01
JO - Journal of Ayurveda and integrative medicine
DO - 10.1016/j.jaim.2026.101395
UR - https://europepmc.org/article/MED/42868873
AB - Background Polyendocrine metabolic ovarian syndrome (PMOS) is a complex, heterogeneous disorder affecting endocrine, reproductive, and metabolic health. It is fundamentally a systemic metabolic defect that, if not addressed in time, can compromise the function of multiple systems, resulting in conditions such as impaired glucose tolerance, insulin resistance, cardiovascular disease, dyslipidemia, fatty liver disease, and type 2 diabetes mellitus. It is a lifestyle disorder with long-term health implications, requiring a holistic approach for management.Methods This prospective quasi-experimental study involved 60 women (30 diagnosed with PMOS, 30 age and BMI-matched controls). Women with PMOS underwent a 12-week Yoga practice that included physical postures (Asanas), regulated breathing practice (Pranayama), and meditation (Dhyana) under the guidance of a trained therapist. Clinical characteristics and laboratory biochemical data were recorded, followed by an untargeted metabolomics analysis using high-resolution Orbitrap Fusion Tribrid Mass Spectrometer technology to study plasma metabolome changes.Results Following Yoga intervention, women with PMOS showed significant improvements in hormonal, anthropometric parameters, and lipid profile. The metabolomics analysis showed that post-Yoga intervention, several key metabolites were significantly downregulated, including glucose, fructose, d-ribose, 3-hydroxybutanoate, taurine, and methylmalonate. However, metabolites like succinate and ascorbate were upregulated. Besides, AUC suggests significant metabolic shifts following Yoga intervention.Conclusion Yoga offers a holistic, integrated mind-body approach to managing the endocrine, metabolic, and reproductive dysfunction in PMOS and lowers the risk of developing long-term comorbidities.
SN - 0975-9476
SN - 0976-2809
ER -