The Epigenomics of Migraine.
- 1Department of Internal Medicine, National Yang-Ming Chiao-Tung University Hospital, Yi-Lan, Taiwan. [email protected].
- 2Institute of Clinical Medicine, School of Medicine, National Yang-Ming Chiao-Tung University, Taipei, Taiwan. [email protected].
Abstract
Purpose of review
To review current evidence on epigenetic mechanisms in migraine, offering insights into diagnosis, disease classification, and future therapeutic management.Recent findings
Recent research has focused on three primary epigenetic mechanisms: DNA methylation, non-coding RNAs, and histone modifications. Altered methylation patterns have been identified in CALCA and RAMP1, both critical components of the CGRP signaling pathway. Furthermore, recent research on non-coding RNA data has enabled the development of composite risk scores to distinguish endophenotypes and support clinical diagnosis. Lastly, the therapeutic efficacy of valproic acid may be mediated via its endogenous histone deacetylase-inhibiting effect and chromatin remodeling. As our understanding of epigenetic modulation in migraine expands, these molecular insights can be integrated with genomic profiles to advance precision medicine, adding value to the interaction between genetic and environmental factors.
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BibTeX
@article{liaw2026epigenomics,
title = {{The Epigenomics of Migraine.}},
author = {Yi-Chia Liaw},
journal = {Current pain and headache reports},
year = {2026},
month = oct,
doi = {10.1007/s11916-026-01574-5},
url = {https://europepmc.org/article/MED/42955189},
note = {CC BY},
}
RIS
TY - JOUR
TI - The Epigenomics of Migraine.
AU - Yi-Chia Liaw
PY - 2026
DA - 2026/10/29
JO - Current pain and headache reports
DO - 10.1007/s11916-026-01574-5
UR - https://europepmc.org/article/MED/42955189
AB - Purpose of review To review current evidence on epigenetic mechanisms in migraine, offering insights into diagnosis, disease classification, and future therapeutic management.Recent findings Recent research has focused on three primary epigenetic mechanisms: DNA methylation, non-coding RNAs, and histone modifications. Altered methylation patterns have been identified in CALCA and RAMP1, both critical components of the CGRP signaling pathway. Furthermore, recent research on non-coding RNA data has enabled the development of composite risk scores to distinguish endophenotypes and support clinical diagnosis. Lastly, the therapeutic efficacy of valproic acid may be mediated via its endogenous histone deacetylase-inhibiting effect and chromatin remodeling. As our understanding of epigenetic modulation in migraine expands, these molecular insights can be integrated with genomic profiles to advance precision medicine, adding value to the interaction between genetic and environmental factors.
SN - 1531-3433
SN - 1534-3081
ER -