Hemorrhagic Transformation after Ischemic Stroke in a Case of Essential Thrombocythemia with…

Abstract

Essential thrombocythemia (ET) is a myeloproliferative neoplasm that is characterized by thrombocytosis. Because it is characterized by thromboembolic and hemorrhagic events, balancing the coagulation status is essential. Thromboelastography (TEG) is a point-of-care viscoelastic test that evaluates whole-blood coagulation dynamics. We herein describe the case of a patient with ischemic stroke accompanied by ET who underwent TEG. The lysis index after 30 min (LY30) was elevated when hemorrhagic transformation occurred. After augmentation with cytoreductive therapy, the platelet count and LY30 levels rapidly normalized. Our findings indicate that TEG may be therefore useful for monitoring the complicated coagulation status of ET patients.

CO‐Rebreathing in Essential Thrombocythemia and Polycythemia Vera. A Revival of an Old Methodology to Improve Diagnosis and Phlebotomy Decisions
Hans C. Hasselbalch, Morten Kranker Larsen, Lea Løffler +8
Cancer Medicine24 Oct 2026Peer-reviewedCC BYFull textHuman geneticsDOAJ
PO023 | CLOPIDOGREL USE IN ANTIPLATELET MANAGEMENT OF ESSENTIAL THROMBOCYTHEMIA (TECLA STUDY): DESIGN AND FEASIBILITY OF A SINGLE-CENTRE STUDY
Paola Ranalli
Bleeding, Thrombosis and Vascular Biology26 Oct 2026Peer-reviewedCC BY-NCFull textCardiovascular medicineDOAJ
Plasma Metabolomic Profiling in Essential Thrombocythemia: Pathway-Level Alterations and Their Relationship to Treatment Status, Platelet Count, and JAK2V617F Status
Batuhan Erdoğdu, Murat Yıldırım, Selim Sayın +12
Metabolites23 Oct 2026Peer-reviewedCC BY 4.0Human geneticsCrossref
CO016 | PLATELET HYPER-REACTIVITY AND PROCOAGULANT PHENOTYPE IN ESSENTIAL THROMBOCYTHEMIA: INSIGHTS FROM ADVANCED PLATELET FUNCTION TESTING
Alessandro Pozzi
Bleeding, Thrombosis and Vascular Biology26 Oct 2026Peer-reviewedCC BY-NCFull textCardiovascular medicineDOAJ
NETs and the thrombo-immune microenvironment: immune heterogeneity in recanalization, reperfusion, hemorrhagic transformation, and antithrombotic strategies
Fangfang Zhu, Feng Wang, Shuhua Wang +2
Frontiers in neurology16 Oct 2026Peer-reviewedCC BYFull textNeurologyEurope PMC

Cite

BibTeX RIS

BibTeX

@article{kudo2026hemorrhagic,
  title = {{Hemorrhagic Transformation after Ischemic Stroke in a Case of Essential Thrombocythemia with Hyperfibrinolysis on Thromboelastography}},
  author = {Daisuke Kudo and Kotaro Noda and Motohiro Suzuki and Yoichiro Nishida},
  journal = {Internal Medicine},
  year = {2026},
  month = jul,
  doi = {10.2169/internalmedicine.6322-25},
  url = {https://www.jstage.jst.go.jp/article/internalmedicine/65/14/65_6322-25/_article},
  note = {CC BY-NC-ND},
}

RIS

TY  - JOUR
TI  - Hemorrhagic Transformation after Ischemic Stroke in a Case of Essential Thrombocythemia with Hyperfibrinolysis on Thromboelastography
AU  - Daisuke Kudo
AU  - Kotaro Noda
AU  - Motohiro Suzuki
AU  - Yoichiro Nishida
PY  - 2026
DA  - 2026/07/15
JO  - Internal Medicine
DO  - 10.2169/internalmedicine.6322-25
UR  - https://www.jstage.jst.go.jp/article/internalmedicine/65/14/65_6322-25/_article
AB  - Essential thrombocythemia (ET) is a myeloproliferative neoplasm that is characterized by thrombocytosis. Because it is characterized by thromboembolic and hemorrhagic events, balancing the coagulation status is essential. Thromboelastography (TEG) is a point-of-care viscoelastic test that evaluates whole-blood coagulation dynamics. We herein describe the case of a patient with ischemic stroke accompanied by ET who underwent TEG. The lysis index after 30 min (LY30) was elevated when hemorrhagic transformation occurred. After augmentation with cytoreductive therapy, the platelet count and LY30 levels rapidly normalized. Our findings indicate that TEG may be therefore useful for monitoring the complicated coagulation status of ET patients.
SN  - 1349-7235
SN  - 0918-2918
ER  -

Abstract

Related

Cite