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PreprintCC BYChemRxiv

Interfacial Solvent Engineering of Zinc Porphyrin Hydrogen-Bonded Organic Frameworks Enables Aggregation-Enhanced Electrochemiluminescence for Synthetic Cannabinoid Sensing

  • Yanpei Zhang1,2,3
  • Ding Jiang1,2
  • Bingxue Fan1,2,3
  • Mingyang Han1,2,3
  • Suran Tian1,2,3
  • Haibo Li4,5
  • Zhidong Chen1,2
5 affiliations
  1. 1Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology, School of Petrochemical Engineering
  2. 2Changzhou University
  3. 3Changzhou University Huaide College
  4. 4Institute of Forensic Science
  5. 5Changzhou Municipal Security Bureau
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Abstract

Zinc porphyrin hydrogen-bonded organic frameworks (ZnTCPP HOFs) are prone to uncontrolled short-range π–π stacking at solid/liquid interfaces, which leads to aggregation-caused quenching (ACQ) and consequently limits their electrochemiluminescence (ECL) efficiency. Current strategies for suppressing ACQ primarily depend on covalent or coordination bonds and often involve laborious synthesis. Addressing this challenge from the perspective of colloid and interface science, this study introduces a chitosan (CS)–DMF counter-solvent precipitation strategy. This approach reorganizes the hydrogen-bond network and fosters electrostatic association between CS and the carboxyl groups of ZnTCPP HOFs, thereby facilitating a controlled transformation of bulk crystals into micro/nano-aggregates. This synergistic effect suppresses short-range π–π stacking while enhancing long-range aggregation-induced emission (AIE), leading to a significant improvement in ECL efficiency without the need for an additional co-reaction promoter. On this basis, an aptamer-based ECL sensor was developed for the ultrasensitive detection of 5F-EDMB-PINACA, achieving a limit of detection of 8.61 × 10 -16 g/L and a linear range spanning nine orders of magnitude. These findings underscore the efficacy of colloidal-interface regulation in ECL sensing.

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Cite

BibTeXRIS
BibTeX
@misc{zhang2026interfacial,
  title = {{Interfacial Solvent Engineering of Zinc Porphyrin Hydrogen-Bonded Organic Frameworks Enables Aggregation-Enhanced Electrochemiluminescence for Synthetic Cannabinoid Sensing}},
  author = {Yanpei Zhang and Ding Jiang and Bingxue Fan and Mingyang Han and Suran Tian and Haibo Li and Zhidong Chen},
  howpublished = {ChemRxiv},
  year = {2026},
  month = sep,
  doi = {10.26434/chemrxiv.15009172/v1},
  url = {https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009172/v1},
  note = {CC BY},
}
RIS
TY  - UNPB
TI  - Interfacial Solvent Engineering of Zinc Porphyrin Hydrogen-Bonded Organic Frameworks Enables Aggregation-Enhanced Electrochemiluminescence for Synthetic Cannabinoid Sensing
AU  - Yanpei Zhang
AU  - Ding Jiang
AU  - Bingxue Fan
AU  - Mingyang Han
AU  - Suran Tian
AU  - Haibo Li
AU  - Zhidong Chen
PY  - 2026
DA  - 2026/09/21
PB  - ChemRxiv
DO  - 10.26434/chemrxiv.15009172/v1
UR  - https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009172/v1
AB  - Zinc porphyrin hydrogen-bonded organic frameworks (ZnTCPP HOFs) are prone to uncontrolled short-range π–π stacking at solid/liquid interfaces, which leads to aggregation-caused quenching (ACQ) and consequently limits their electrochemiluminescence (ECL) efficiency. Current strategies for suppressing ACQ primarily depend on covalent or coordination bonds and often involve laborious synthesis. Addressing this challenge from the perspective of colloid and interface science, this study introduces a chitosan (CS)–DMF counter-solvent precipitation strategy. This approach reorganizes the hydrogen-bond network and fosters electrostatic association between CS and the carboxyl groups of ZnTCPP HOFs, thereby facilitating a controlled transformation of bulk crystals into micro/nano-aggregates. This synergistic effect suppresses short-range π–π stacking while enhancing long-range aggregation-induced emission (AIE), leading to a significant improvement in ECL efficiency without the need for an additional co-reaction promoter. On this basis, an aptamer-based ECL sensor was developed for the ultrasensitive detection of 5F-EDMB-PINACA, achieving a limit of detection of 8.61 × 10 -16 g/L and a linear range spanning nine orders of magnitude. These findings underscore the efficacy of colloidal-interface regulation in ECL sensing.
ER  -