Voxelwise degree centrality alterations and cognitive performance in severe unilateral M1-segment middle cerebral artery stenosis with ipsilateral watershed infarction.
- 1Department of Neurology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, China.
- 2Department of Geriatrics, The Second Affiliated Hospital of Guangxi Medical University, Nanning, China.
- 3Department of Neurology, The People's Hospital of Chongzuo, Chongzuo, China.
Abstract
Purpose
To characterize voxelwise degree centrality (DC) alterations and their exploratory clinical associations in severe unilateral M1-segment middle cerebral artery stenosis with ipsilateral watershed infarction.Methods
This cross-sectional study included 40 patients with left-sided disease, 47 with right-sided disease, and 44 healthy controls. Resting-state functional magnetic resonance imaging-derived weighted DC (r > 0.25) was compared using analysis of covariance with adjustment for educational attainment, Tukey-Kramer testing, and Gaussian random field-corrected patient-control contrasts (two-tailed voxel P < 0.001; cluster P < 0.05). Exploratory clinical associations were assessed using Spearman rank correlation.Results
Mini-Mental State Examination (MMSE) scores differed among groups (P < 0.001), with both patient groups scoring lower than controls; Montreal Cognitive Assessment (MoCA) scores also differed (P < 0.001), with the left-sided group lowest, the right-sided group intermediate, and controls highest. The left-sided group showed lower DC predominantly in left temporal-opercular and postcentral-inferior parietal regions and higher DC in right medial/subcortical and posterior-midline regions; the largest lower-DC cluster peaked at MNI coordinates -48, -18, 39 (Z = -5.5420). The right-sided group showed lower DC in right putaminal/insular, temporal, and parietal-sensorimotor regions and higher DC in the left cerebellum; the largest lower-DC cluster peaked at MNI coordinates 48, -27, 36 (Z = -6.0021). In the right-sided group, exploratory nominal associations were observed between MMSE scores and DC in the left cerebellar, right superior temporal-pole, and right parietal-sensorimotor clusters (r = -0.300 to 0.421; nominal P = 0.003-0.040). No nominal cognitive-DC correlations were observed in the left-sided group, and no MoCA-DC correlations in the right-sided group.Conclusion
Distributed DC alterations accompanied cognitive performance differences, with selective exploratory nominal MMSE associations in right-sided disease. DC may merit further evaluation as a candidate imaging feature of BOLD-based functional alterations associated with cognitive differences.
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BibTeX
@article{huang2026voxelwise,
title = {{Voxelwise degree centrality alterations and cognitive performance in severe unilateral M1-segment middle cerebral artery stenosis with ipsilateral watershed infarction.}},
author = {Zhilin Huang and Xiaoxue Liang and Liyong Li and Yude Wei and Yi Zhang and Wenqian Wei and Xuanmei Quan and Kanglei Li and Kunlong Yao and Jian Tang and Yueling Zhang and Jianyi Huang and Jian Zhang},
journal = {Frontiers in aging neuroscience},
year = {2026},
month = oct,
doi = {10.3389/fnagi.2026.1969092},
url = {https://europepmc.org/article/MED/42909121},
note = {CC BY},
}
RIS
TY - JOUR
TI - Voxelwise degree centrality alterations and cognitive performance in severe unilateral M1-segment middle cerebral artery stenosis with ipsilateral watershed infarction.
AU - Zhilin Huang
AU - Xiaoxue Liang
AU - Liyong Li
AU - Yude Wei
AU - Yi Zhang
AU - Wenqian Wei
AU - Xuanmei Quan
AU - Kanglei Li
AU - Kunlong Yao
AU - Jian Tang
AU - Yueling Zhang
AU - Jianyi Huang
AU - Jian Zhang
PY - 2026
DA - 2026/10/07
JO - Frontiers in aging neuroscience
DO - 10.3389/fnagi.2026.1969092
UR - https://europepmc.org/article/MED/42909121
AB - Purpose To characterize voxelwise degree centrality (DC) alterations and their exploratory clinical associations in severe unilateral M1-segment middle cerebral artery stenosis with ipsilateral watershed infarction.Methods This cross-sectional study included 40 patients with left-sided disease, 47 with right-sided disease, and 44 healthy controls. Resting-state functional magnetic resonance imaging-derived weighted DC (r > 0.25) was compared using analysis of covariance with adjustment for educational attainment, Tukey-Kramer testing, and Gaussian random field-corrected patient-control contrasts (two-tailed voxel P < 0.001; cluster P < 0.05). Exploratory clinical associations were assessed using Spearman rank correlation.Results Mini-Mental State Examination (MMSE) scores differed among groups (P < 0.001), with both patient groups scoring lower than controls; Montreal Cognitive Assessment (MoCA) scores also differed (P < 0.001), with the left-sided group lowest, the right-sided group intermediate, and controls highest. The left-sided group showed lower DC predominantly in left temporal-opercular and postcentral-inferior parietal regions and higher DC in right medial/subcortical and posterior-midline regions; the largest lower-DC cluster peaked at MNI coordinates -48, -18, 39 (Z = -5.5420). The right-sided group showed lower DC in right putaminal/insular, temporal, and parietal-sensorimotor regions and higher DC in the left cerebellum; the largest lower-DC cluster peaked at MNI coordinates 48, -27, 36 (Z = -6.0021). In the right-sided group, exploratory nominal associations were observed between MMSE scores and DC in the left cerebellar, right superior temporal-pole, and right parietal-sensorimotor clusters (r = -0.300 to 0.421; nominal P = 0.003-0.040). No nominal cognitive-DC correlations were observed in the left-sided group, and no MoCA-DC correlations in the right-sided group.Conclusion Distributed DC alterations accompanied cognitive performance differences, with selective exploratory nominal MMSE associations in right-sided disease. DC may merit further evaluation as a candidate imaging feature of BOLD-based functional alterations associated with cognitive differences.
SN - 1663-4365
ER -