Severe upper gastrointestinal hemorrhage in a renal transplant recipient: A potential complication of immunosuppressive therapy
- 1Internal Medicine Residency Program (IMRP), Division of Internal Medicine, Hamad Medical Corporation, Doha, Qatar
- 2Department of Gastroenterology, Hamad Medical Corporation, Doha, Qatar
Abstract
Upper gastrointestinal bleed (UGIB) is a significant and potentially life-threatening complication in renal transplant recipients, frequently associated with immunosuppressive therapy. We present a case of a 38-year-old male renal transplant recipient who experienced recurrent UGIB due to duodenal and gastric ulcers during the early postoperative period. His immunosuppressive regimen, initially consisting of antithymocyte globulin, steroids, tacrolimus, and mycophenolate mofetil (MMF), was adjusted multiple times in response to persistent bleeding episodes. Despite numerous endoscopic, radiological, and surgical interventions, his condition necessitated further immunosuppressive modulation, including cessation of MMF and introduction of belatacept, which ultimately stabilized his gastrointestinal condition. This case underscores the complexities of managing UGIB in renal transplant recipients under immunosuppressive therapy and highlights the need for a tailored multidisciplinary approach to optimize outcomes while preserving graft function.
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BibTeX
@article{mahmoud2026severe,
title = {{Severe upper gastrointestinal hemorrhage in a renal transplant recipient: A potential complication of immunosuppressive therapy}},
author = {Elhassan Mahmoud and Yousra Ali and Ibrahim M. Obeidat and Souraia Mezhoud and Rafie A. Yakoob},
journal = {SAGE Open Medical Case Reports},
year = {2026},
month = sep,
doi = {10.1177/2050313x261420025},
url = {https://doi.org/10.1177/2050313x261420025},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Severe upper gastrointestinal hemorrhage in a renal transplant recipient: A potential complication of immunosuppressive therapy
AU - Elhassan Mahmoud
AU - Yousra Ali
AU - Ibrahim M. Obeidat
AU - Souraia Mezhoud
AU - Rafie A. Yakoob
PY - 2026
DA - 2026/09/19
JO - SAGE Open Medical Case Reports
DO - 10.1177/2050313x261420025
UR - https://doi.org/10.1177/2050313x261420025
AB - Upper gastrointestinal bleed (UGIB) is a significant and potentially life-threatening complication in renal transplant recipients, frequently associated with immunosuppressive therapy. We present a case of a 38-year-old male renal transplant recipient who experienced recurrent UGIB due to duodenal and gastric ulcers during the early postoperative period. His immunosuppressive regimen, initially consisting of antithymocyte globulin, steroids, tacrolimus, and mycophenolate mofetil (MMF), was adjusted multiple times in response to persistent bleeding episodes. Despite numerous endoscopic, radiological, and surgical interventions, his condition necessitated further immunosuppressive modulation, including cessation of MMF and introduction of belatacept, which ultimately stabilized his gastrointestinal condition. This case underscores the complexities of managing UGIB in renal transplant recipients under immunosuppressive therapy and highlights the need for a tailored multidisciplinary approach to optimize outcomes while preserving graft function.
SN - 2050-313X
ER -