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Peer-reviewedLicence not statedMolecular cell

An Epigenetic Program Dictates MYC Amplification Dynamics that Promote Transient, Extrachromosomal and Inherited Genomic Events

  • Benjamin I. Ferman1,2,3,4
  • Chloe Azadegan1,2,3,5
  • John Santoro1,2,3
  • Anushka Udara1,2,3,6
  • Madison A. Lineberger1,2,3,4
  • William Lautert-Dutra1,2,3,6
  • Ethan Sumner1,2,3
  • Logan McCullough1,2,3
  • Erin O’Donnell1,2,3,6
  • Kashish Chetal7
  • Jade Wilson1,2,3,4
  • Zach Gray1,2,3,4
15 more authors
  • Manna Ahmed1,2,3
  • Zhijie Deng8
  • Yan Xiong8
  • H Umit Kaniskan8
  • Damayanti Chakraborty9
  • Thomas L. Clarke9
  • Sedona E. Murphy9
  • Martin Walsh1,2,3
  • Alfonso Bellacosa1,2,3
  • Hayan Lee1,2,3
  • Jian Jin8
  • Capucine Van Rechem9,10
  • Michael S. Lawrence11,12
  • Ruslan I. Sadreyev7,13
  • Johnathan R. Whetstine1,2,3
13 affiliations
  1. 1Cancer Epigenetics Institute, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
  2. 2Nuclear Dynamics and Cancer Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
  3. 3Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
  4. 4Biomedical Science Graduate Program, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 19140, USA
  5. 5Program in Molecular & Cellular Biology & Genetics, Drexel University College of Medicine, Philadelphia, PA, 19104, USA
  6. 6College of Science and Technology, Temple University, Philadelphia, PA, 19140, USA
  7. 7Massachusetts General Hospital Department of Molecular Biology, Boston, MA 02114, USA
  8. 8Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences, Oncological Sciences and Neuroscience, The Mount Sinai Tisch Cancer Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
  9. 9Massachusetts General Hospital Cancer Center and Harvard Medical School Department of Medicine, Charlestown, MA, 02129, USA
  10. 10Department of Pathology, Stanford University, Stanford, CA, 94305, USA
  11. 11Broad Institute of Harvard and MIT, Cambridge, MA 02114, USA
  12. 12Massachusetts General Hospital Krantz Family Center for Cancer Research and Harvard Medical School Department of Medicine, Charlestown, MA 02129, USA
  13. 13Massachusetts General Hospital Department of Pathology and Harvard Medical School, Boston, MA 02114, USA
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Cite

BibTeXRIS
BibTeX
@article{ferman2026epigenetic,
  title = {{An Epigenetic Program Dictates MYC Amplification Dynamics that Promote Transient, Extrachromosomal and Inherited Genomic Events}},
  author = {Benjamin I. Ferman and Chloe Azadegan and John Santoro and Anushka Udara and Madison A. Lineberger and William Lautert-Dutra and Ethan Sumner and Logan McCullough and Erin O’Donnell and Kashish Chetal and Jade Wilson and Zach Gray and Manna Ahmed and Zhijie Deng and Yan Xiong and H Umit Kaniskan and Damayanti Chakraborty and Thomas L. Clarke and Sedona E. Murphy and Martin Walsh and Alfonso Bellacosa and Hayan Lee and Jian Jin and Capucine Van Rechem and Michael S. Lawrence and Ruslan I. Sadreyev and Johnathan R. Whetstine},
  journal = {Molecular cell},
  year = {2026},
  month = oct,
  doi = {10.1016/j.molcel.2026.09.032},
  url = {https://doi.org/10.1016/j.molcel.2026.09.032},
}
RIS
TY  - JOUR
TI  - An Epigenetic Program Dictates MYC Amplification Dynamics that Promote Transient, Extrachromosomal and Inherited Genomic Events
AU  - Benjamin I. Ferman
AU  - Chloe Azadegan
AU  - John Santoro
AU  - Anushka Udara
AU  - Madison A. Lineberger
AU  - William Lautert-Dutra
AU  - Ethan Sumner
AU  - Logan McCullough
AU  - Erin O’Donnell
AU  - Kashish Chetal
AU  - Jade Wilson
AU  - Zach Gray
AU  - Manna Ahmed
AU  - Zhijie Deng
AU  - Yan Xiong
AU  - H Umit Kaniskan
AU  - Damayanti Chakraborty
AU  - Thomas L. Clarke
AU  - Sedona E. Murphy
AU  - Martin Walsh
AU  - Alfonso Bellacosa
AU  - Hayan Lee
AU  - Jian Jin
AU  - Capucine Van Rechem
AU  - Michael S. Lawrence
AU  - Ruslan I. Sadreyev
AU  - Johnathan R. Whetstine
PY  - 2026
DA  - 2026/10/02
JO  - Molecular cell
DO  - 10.1016/j.molcel.2026.09.032
UR  - https://doi.org/10.1016/j.molcel.2026.09.032
SN  - 1097-2765
SN  - 1097-4164
ER  -