Interrogating vascular determinants of repair: Biofabricated constructs for precision intervention in peripheral neuropathies
- 1Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Zhejiang Key Laboratory of Oral Biomedical, Hangzhou, 310000, China
Abstract
Peripheral neuropathies (PN) exact a devastating global toll, manifest across traumatic and non-traumatic spectra and culminating in intractable pain, sensorimotor impairment, and chronic disablement. Converging upon a shared pathological crux, these conditions implicate destabilization of the neurovascular niche, a derangement that impairs perfusion, metabolic supply, and axonal pathfinding signals. Vascular dysfunction thus constitutes a unifying therapeutic lever. Synthesizing clinical, bibliometric, and single-cell transcriptomic evidence, this review delineates neurovascular crosstalk as instrumental to both disease progression and regenerative capacity. Advanced biomaterial-enabled, vascular-guided engineering platforms, refined through contemporary fabrication technologies, present incisive interventions to surmount this barrier. Therapeutic strategies are demarcated by PN subtype, while modifications aimed at promoting concurrent angiogenesis and neural repair receive exhaustive exposition. Prevailing evidence consolidates in advocacy of a vasculocentric framework. Translational impediments and emergent prospects are surveyed to accelerate clinical fruition.
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BibTeX
@article{sun2026interrogating,
title = {{Interrogating vascular determinants of repair: Biofabricated constructs for precision intervention in peripheral neuropathies}},
author = {Mouyuan Sun and Shuangyang Li and Xuankai Fan and Yiqian Xu and Yaxian Luo and Luying Qin and Jingyu Zhang and Z Y He and Lianjie Peng and X Xiuzhen Feng and Tao Qiu and Tian Zhang and Huiming Wang and Mengfei Yu and Wanghui Ding},
journal = {Chemical Engineering Journal},
year = {2026},
month = jul,
doi = {10.1016/j.cej.2026.179095},
url = {https://doi.org/10.1016/j.cej.2026.179095},
note = {CC BY},
}
RIS
TY - JOUR
TI - Interrogating vascular determinants of repair: Biofabricated constructs for precision intervention in peripheral neuropathies
AU - Mouyuan Sun
AU - Shuangyang Li
AU - Xuankai Fan
AU - Yiqian Xu
AU - Yaxian Luo
AU - Luying Qin
AU - Jingyu Zhang
AU - Z Y He
AU - Lianjie Peng
AU - X Xiuzhen Feng
AU - Tao Qiu
AU - Tian Zhang
AU - Huiming Wang
AU - Mengfei Yu
AU - Wanghui Ding
PY - 2026
DA - 2026/07/04
JO - Chemical Engineering Journal
DO - 10.1016/j.cej.2026.179095
UR - https://doi.org/10.1016/j.cej.2026.179095
AB - Peripheral neuropathies (PN) exact a devastating global toll, manifest across traumatic and non-traumatic spectra and culminating in intractable pain, sensorimotor impairment, and chronic disablement. Converging upon a shared pathological crux, these conditions implicate destabilization of the neurovascular niche, a derangement that impairs perfusion, metabolic supply, and axonal pathfinding signals. Vascular dysfunction thus constitutes a unifying therapeutic lever. Synthesizing clinical, bibliometric, and single-cell transcriptomic evidence, this review delineates neurovascular crosstalk as instrumental to both disease progression and regenerative capacity. Advanced biomaterial-enabled, vascular-guided engineering platforms, refined through contemporary fabrication technologies, present incisive interventions to surmount this barrier. Therapeutic strategies are demarcated by PN subtype, while modifications aimed at promoting concurrent angiogenesis and neural repair receive exhaustive exposition. Prevailing evidence consolidates in advocacy of a vasculocentric framework. Translational impediments and emergent prospects are surveyed to accelerate clinical fruition.
SN - 1385-8947
SN - 1873-3212
ER -