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Peer-reviewedLicence not statedScience

Cross-cohort analysis of expression and splicing quantitative trait loci in TOPMed

  • Peter Orchard1,2
  • Thomas W. Blackwell3,4,2
  • Linda Kachuri5,6
  • Peter J. Castaldi7,8
  • Michael H. Cho7,8
  • Stephanie A. Christenson9,10
  • Peter Durda11,12
  • Stacey Gabriel13,14
  • Craig P. Hersh7,15,8
  • Scott Huntsman16,10
  • S.-J. Hwang17,6
  • Roby Joehanes18,19,20
88 more authors
  • Mari Johnson21,22
  • Xingnan Li23,24,25
  • Honghuang Lin26,18,27
  • Ching‐Ti Liu28,29
  • Yongmei Liu30,31,32
  • Angel C. Y. Mak16,10
  • Ani W Manichaikul33,34
  • David T. Paik35,6
  • Aabida Saferali7,8
  • Joshua D. Smith36,37
  • Kent D. Taylor38,39
  • Russell P. Tracy40,12
  • Jiongming Wang4,2
  • Mingqiang Wang35,6
  • Joshua S. Weinstock
  • Jeffrey Weiss36,37
  • Heather E. Wheeler
  • Ying Zhou21,22
  • Sebastian Zoellner3,4,2
  • Joseph C. Wu35,6
  • Luisa Mestroni
  • Sharon Louise Graw
  • Matthew R.G. Taylor
  • Victor E. Ortega
  • Craig W Johnson37
  • Weiniu Gan
  • Gonçalo Abecasis3,4,2
  • Deborah A. Nickerson36,37
  • Namrata Gupta13,14
  • Kristin Ardlie13,14
  • Prescott G. Woodruff9,10
  • Russell Paul Bowler
  • Deborah A. Meyers
  • Alex P. Reiner
  • Charles L Kooperberg21,37
  • Elad Ziv16,22
  • Ramachandran Srini Vasan18,10
  • Martin G. Larson18
  • L. Adrienne Cupples28,18
  • Edwin K. Silverman7,15
  • Stephen S. Rich33,10
  • Nancy L. Heard‐Costa8
  • Hua Tang17,34
  • Jerome I. Rotter38,29
  • Albert V. Smith3,4,6
  • Daniel A Levy18,19,39
  • François Aguet13,2
  • Laura J. Scott3,4,20

60 listed; 100 in total.

40 affiliations
  1. 1Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA
  2. 2University of Michigan
  3. 3Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI, USA
  4. 4Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA
  5. 5Department of Epidemiology and Population Health, School of Medicine, Stanford University, Stanford, CA, USA
  6. 6Stanford University
  7. 7Channing Division of Network Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
  8. 8Brigham and Women's Hospital, Harvard Medical School
  9. 9Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, School of Medicine, University of California, San Francisco, San Francisco, CA, USA
  10. 10University of California, San Francisco
  11. 11Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, VT, USA
  12. 12University of Vermont
  13. 13Broad Institute of MIT and Harvard, Cambridge, MA, USA
  14. 14Broad Institute of MIT & Harvard
  15. 15Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
  16. 16Department of Medicine, University of California, San Francisco, San Francisco, CA, USA
  17. 17Department of Genetics, Stanford University, Stanford, CA, USA
  18. 18Framingham Heart Study, National Heart, Lung, and Blood Institute, National Institutes of Health and Boston University, Framingham, MA, USA
  19. 19Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
  20. 20National Heart, Lung, and Blood Institute, National Institutes of Health and Boston University
  21. 21Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA
  22. 22Fred Hutchinson Cancer Center
  23. 23Division of Data Driven and Digital Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA
  24. 24Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA
  25. 25Icahn School of Medicine at Mount Sanai
  26. 26Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA
  27. 27University of Massachusetts
  28. 28Department of Biostatistics, School of Public Health, Boston University, Boston, MA, USA
  29. 29Boston University
  30. 30Division of Cardiology, Department of Medicine, School of Medicine, Duke University, Durham, NC, USA
  31. 31Stanford University, Stanford, CA, USA
  32. 32Duke University
  33. 33Department of Genome Sciences, School of Medicine, University of Virginia, Charlottesville, VA, USA
  34. 34University of Virginia
  35. 35Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA
  36. 36Northwest Genomics Center, University of Washington, Seattle, WA, USA
  37. 37University of Washington
  38. 38The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA
  39. 39The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
  40. 40Laboratory for Clinical Biochemistry Research, Larner College of Medicine, University of Vermont, Burlington, VT, USA
Open at sourcePDFDOICite

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Cite

BibTeXRIS
BibTeX
@article{orchard2026crosscohort,
  title = {{Cross-cohort analysis of expression and splicing quantitative trait loci in TOPMed}},
  author = {Peter Orchard and Thomas W. Blackwell and Linda Kachuri and Peter J. Castaldi and Michael H. Cho and Stephanie A. Christenson and Peter Durda and Stacey Gabriel and Craig P. Hersh and Scott Huntsman and S.-J. Hwang and Roby Joehanes and Mari Johnson and Xingnan Li and Honghuang Lin and Ching‐Ti Liu and Yongmei Liu and Angel C. Y. Mak and Ani W Manichaikul and David T. Paik and Aabida Saferali and Joshua D. Smith and Kent D. Taylor and Russell P. Tracy and Jiongming Wang and Mingqiang Wang and Joshua S. Weinstock and Jeffrey Weiss and Heather E. Wheeler and Ying Zhou and Sebastian Zoellner and Joseph C. Wu and Luisa Mestroni and Sharon Louise Graw and Matthew R.G. Taylor and Victor E. Ortega and Craig W Johnson and Weiniu Gan and Gonçalo Abecasis and Deborah A. Nickerson and Namrata Gupta and Kristin Ardlie and Prescott G. Woodruff and Russell Paul Bowler and Deborah A. Meyers and Alex P. Reiner and Charles L Kooperberg and Elad Ziv and Ramachandran Srini Vasan and Martin G. Larson and L. Adrienne Cupples and Edwin K. Silverman and Stephen S. Rich and Nancy L. Heard‐Costa and Hua Tang and Jerome I. Rotter and Albert V. Smith and Daniel A Levy and François Aguet and Laura J. Scott},
  journal = {Science},
  year = {2026},
  month = jul,
  doi = {10.1126/science.adx2989},
  url = {https://doi.org/10.1101/2025.02.19.25322561},
}
RIS
TY  - JOUR
TI  - Cross-cohort analysis of expression and splicing quantitative trait loci in TOPMed
AU  - Peter Orchard
AU  - Thomas W. Blackwell
AU  - Linda Kachuri
AU  - Peter J. Castaldi
AU  - Michael H. Cho
AU  - Stephanie A. Christenson
AU  - Peter Durda
AU  - Stacey Gabriel
AU  - Craig P. Hersh
AU  - Scott Huntsman
AU  - S.-J. Hwang
AU  - Roby Joehanes
AU  - Mari Johnson
AU  - Xingnan Li
AU  - Honghuang Lin
AU  - Ching‐Ti Liu
AU  - Yongmei Liu
AU  - Angel C. Y. Mak
AU  - Ani W Manichaikul
AU  - David T. Paik
AU  - Aabida Saferali
AU  - Joshua D. Smith
AU  - Kent D. Taylor
AU  - Russell P. Tracy
AU  - Jiongming Wang
AU  - Mingqiang Wang
AU  - Joshua S. Weinstock
AU  - Jeffrey Weiss
AU  - Heather E. Wheeler
AU  - Ying Zhou
AU  - Sebastian Zoellner
AU  - Joseph C. Wu
AU  - Luisa Mestroni
AU  - Sharon Louise Graw
AU  - Matthew R.G. Taylor
AU  - Victor E. Ortega
AU  - Craig W Johnson
AU  - Weiniu Gan
AU  - Gonçalo Abecasis
AU  - Deborah A. Nickerson
AU  - Namrata Gupta
AU  - Kristin Ardlie
AU  - Prescott G. Woodruff
AU  - Russell Paul Bowler
AU  - Deborah A. Meyers
AU  - Alex P. Reiner
AU  - Charles L Kooperberg
AU  - Elad Ziv
AU  - Ramachandran Srini Vasan
AU  - Martin G. Larson
AU  - L. Adrienne Cupples
AU  - Edwin K. Silverman
AU  - Stephen S. Rich
AU  - Nancy L. Heard‐Costa
AU  - Hua Tang
AU  - Jerome I. Rotter
AU  - Albert V. Smith
AU  - Daniel A Levy
AU  - François Aguet
AU  - Laura J. Scott
PY  - 2026
DA  - 2026/07/16
JO  - Science
DO  - 10.1126/science.adx2989
UR  - https://doi.org/10.1101/2025.02.19.25322561
SN  - 0036-8075
SN  - 0193-4511
SN  - 1095-9203
ER  -