The influence of surface functionalization and signal transduction on electrochemical aptamer-based sensors
Abstract
Electrochemical aptamer-based (E-AB) sensors are a major topic of research, yet their transition from laboratory proof-of-concept to robust real-life applications remains limited. This phenomenon can partly be explained by examining the fundamental physicochemical challenges at the bio-interface. This review provides a critical perspective on two decisive factors: interfacial functionalization and electrochemical interrogation. We argue that because E-AB performance is governed by electron transfer at the electrode-electrolyte boundary, the choice of immobilization chemistry is an important factor for analytical stability and sensitivity. Furthermore, we exemplify how different electrochemical techniques, ranging from square-wave voltammetry to impedimetric methods, impact electrode longevity and signal reliability. We believe the two aspects are the main contributing factors influencing the performance of E-AB sensors.
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BibTeX
@article{lupoi2026influence,
title = {{The influence of surface functionalization and signal transduction on electrochemical aptamer-based sensors}},
author = {Teodora Lupoi and Yann R. Leroux and Florence Geneste},
journal = {Current Opinion in Electrochemistry},
year = {2026},
month = oct,
doi = {10.1016/j.coelec.2026.101933},
url = {https://hal.science/hal-05741463v1},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - The influence of surface functionalization and signal transduction on electrochemical aptamer-based sensors
AU - Teodora Lupoi
AU - Yann R. Leroux
AU - Florence Geneste
PY - 2026
DA - 2026/10/14
JO - Current Opinion in Electrochemistry
DO - 10.1016/j.coelec.2026.101933
UR - https://hal.science/hal-05741463v1
AB - Electrochemical aptamer-based (E-AB) sensors are a major topic of research, yet their transition from laboratory proof-of-concept to robust real-life applications remains limited. This phenomenon can partly be explained by examining the fundamental physicochemical challenges at the bio-interface. This review provides a critical perspective on two decisive factors: interfacial functionalization and electrochemical interrogation. We argue that because E-AB performance is governed by electron transfer at the electrode-electrolyte boundary, the choice of immobilization chemistry is an important factor for analytical stability and sensitivity. Furthermore, we exemplify how different electrochemical techniques, ranging from square-wave voltammetry to impedimetric methods, impact electrode longevity and signal reliability. We believe the two aspects are the main contributing factors influencing the performance of E-AB sensors.
SN - 2451-9103
SN - 2451-9103
ER -