Skip to content
DraconiticResearch
Search Sources API
203,234 studies31 sourcesUpdated 24 min ago
Peer-reviewedCC BY-NCInternational journal of nanomedicine

Platelet-Tumor Interactions: From Mechanisms Promoting Metastasis to Novel Targeted Therapeutic Strategies.

  • Wanyi Liu1,2
  • Yuan Zhu1,2
  • Tao Wang1,2
  • Yuying Yuan1,2
  • Xi Yu1,2
  • Yongqiang Zhu2
  • Peihao Yin3
  • Wei Li4
  • Zeting Yuan1
4 affiliations
  1. 1Central Laboratory, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200062, People's Republic of China.
  2. 2Interventional Cancer Institute of Chinese Integrative Medicine, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200062, People's Republic of China.
  3. 3Department of General Surgery, Putuo People's Hospital, School of Medicine, Tongji University, Shanghai, 200060, People's Republic of China.
  4. 4Department of General Surgery, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200062, People's Republic of China.
Read full textPDFDOICite

Abstract

Platelets are anucleate blood cells that primarily mediate hemostasis and thrombosis. Tumor metastasis represents the leading cause of mortality among cancer patients, and platelet-mediated hematogenous metastasis constitutes a critical step facilitating the dissemination of tumor cells. A wealth of evidence has demonstrated a close correlation between platelets and tumor progression. Platelets aggregate around circulating tumor cells (CTCs) and drive tumor metastasis via multiple mechanisms: shielding CTCs from hemodynamic shear stress and immune cell attack, inducing epithelial-mesenchymal transition (EMT), promoting the formation of pre-metastatic niches (PMNs), and enabling immune evasion. Targeted therapeutic strategies built on the interplay between platelets and tumors are of great significance for restraining tumor metastasis and prolonging patient survival. This review comprehensively elaborates on the mechanisms by which platelets promote tumor metastasis, summarizes the merits and relevant strategies of platelet-targeted therapies, and offers novel insights for the suppression of tumor metastasis.

Related

  1. Bone Metastasis and the Immunosuppressive Tumor Microenvironment: Mechanisms and Therapeutic Strategies
    Minghao Ba, Yuzhu Chen, Peng Jiang +3
    Oncology ResearchPeer-reviewedCC BY 4.0Full textOncologyPMC
  2. The Dark Side of Radiotherapy: Experimental Evidence, Biological Mechanisms, and Preventive Strategies for Radiation-Induced Tumor-Promoting Niches
    BiomedicinesPeer-reviewedCC BYFull textGeneral medicineEurope PMC
  3. Editorial: Immunology of human fungal pathogens: host-pathogen interactions, immune evasion, and therapeutic strategies
    Iván Martínez-Duncker, Andrea Regina de Souza Baptista, Héctor M. Mora Montes
    Frontiers in ImmunologyPeer-reviewedCC BY 4.0Full textInfectious diseaseCrossref
  4. Cancer metastasis: biological mechanisms, therapeutic bottlenecks, and emerging interventions.
    Huali Ye, Yuquan Wei, Xuemei He +1
    Journal of hematology & oncologyPeer-reviewedCC BY-NC-NDFull textOncologyEurope PMCDOAJ
  5. Exploring immunotherapy resistance in bone metastasis: mechanisms and optimization of combined treatment strategies-a narrative review.
    Junquan Zhu, Min Li
    Translational cancer researchPeer-reviewedCC BY-NC-NDFull textOncologyEurope PMC

Cite

BibTeXRIS
BibTeX
@article{liu2026platelettumor,
  title = {{Platelet-Tumor Interactions: From Mechanisms Promoting Metastasis to Novel Targeted Therapeutic Strategies.}},
  author = {Wanyi Liu and Yuan Zhu and Tao Wang and Yuying Yuan and Xi Yu and Yongqiang Zhu and Peihao Yin and Wei Li and Zeting Yuan},
  journal = {International journal of nanomedicine},
  year = {2026},
  month = nov,
  doi = {10.2147/ijn.s649895},
  url = {https://europepmc.org/article/MED/42999852},
  note = {CC BY-NC},
}
RIS
TY  - JOUR
TI  - Platelet-Tumor Interactions: From Mechanisms Promoting Metastasis to Novel Targeted Therapeutic Strategies.
AU  - Wanyi Liu
AU  - Yuan Zhu
AU  - Tao Wang
AU  - Yuying Yuan
AU  - Xi Yu
AU  - Yongqiang Zhu
AU  - Peihao Yin
AU  - Wei Li
AU  - Zeting Yuan
PY  - 2026
DA  - 2026/11/03
JO  - International journal of nanomedicine
DO  - 10.2147/ijn.s649895
UR  - https://europepmc.org/article/MED/42999852
AB  - Platelets are anucleate blood cells that primarily mediate hemostasis and thrombosis. Tumor metastasis represents the leading cause of mortality among cancer patients, and platelet-mediated hematogenous metastasis constitutes a critical step facilitating the dissemination of tumor cells. A wealth of evidence has demonstrated a close correlation between platelets and tumor progression. Platelets aggregate around circulating tumor cells (CTCs) and drive tumor metastasis via multiple mechanisms: shielding CTCs from hemodynamic shear stress and immune cell attack, inducing epithelial-mesenchymal transition (EMT), promoting the formation of pre-metastatic niches (PMNs), and enabling immune evasion. Targeted therapeutic strategies built on the interplay between platelets and tumors are of great significance for restraining tumor metastasis and prolonging patient survival. This review comprehensively elaborates on the mechanisms by which platelets promote tumor metastasis, summarizes the merits and relevant strategies of platelet-targeted therapies, and offers novel insights for the suppression of tumor metastasis.
SN  - 1176-9114
SN  - 1178-2013
ER  -