Unraveling the Promising Role of Phytochemical-Based Therapies and Their Novel Delivery Systems in the Prevention and Treatment of Oral Diseases
5 affiliations
- 1Department of Pharmaceutics and Pharmaceutical Nanotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran 1996835113, Iran
- 2Software Engineering Department, Engineering and Natural Sciences Faculty, Istanbul Topkapi University, Istanbul 34087, Turkey
- 3Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran 1996835113, Iran
- 4Research Center for Advanced Technologies in Cardiovascular Medicine, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran 1996835113, Iran
- 5Protein Technology Research Center, Shahid Beheshti University of Medical Sciences, Tehran 1996835113, Iran
Abstract
Oral diseases have affected a large population worldwide. Phytochemicals have shown antioxidant, antibacterial, and anti-cancer properties, suggesting their potential for managing oral diseases. Conventional dosage forms containing phytochemicals are commercially available and have demonstrated promising effects in oral conditions. Recently, numerous phytochemical-based novel delivery systems (liposomes, niosomes, nanoparticles, nanofibers, hydrogels, etc.) have also been prepared to improve the efficacy of phytochemicals in managing the conditions discussed here. These novel delivery systems can improve local retention, protect phytochemicals from degradation, enhance penetration and bioavailability, and provide controlled or sustained release. This review therefore offers a delivery-system-focused perspective. Research articles from 2013 to 2026 were systematically reviewed. Preclinical and clinical applications of phenolic compounds (catechins, curcumin, quercetin, and resveratrol), carotenoids (lycopene, astaxanthin, and β-carotene), and alkaloids (berberine and piperine) for managing periodontal diseases, oral cancers, potentially malignant oral disorders, dental caries, oral candidiasis, and oral ulcers are summarized. The article provides an overview of oral diseases, classification, common phytochemicals, mechanisms, and clinical improvements. Finally, conventional and novel drug delivery systems loaded with phytochemicals are discussed. This work explores challenges and outlines future directions, with special attention to the role of artificial intelligence.
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BibTeX
@article{goshtasbi2026unraveling,
title = {{Unraveling the Promising Role of Phytochemical-Based Therapies and Their Novel Delivery Systems in the Prevention and Treatment of Oral Diseases}},
author = {Nazanin Goshtasbi and Maryam Ebrahimnia and Mahsa Torkamanian-Afshar and Yasaman Rezaee and Sina Moayeri Jolandan and Farnoosh Farahani and Shahram Rabbani and Azadeh Haeri},
journal = {Biomolecules},
year = {2026},
month = nov,
doi = {10.3390/biom16111614},
url = {https://www.mdpi.com/2218-273X/16/11/1614},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Unraveling the Promising Role of Phytochemical-Based Therapies and Their Novel Delivery Systems in the Prevention and Treatment of Oral Diseases
AU - Nazanin Goshtasbi
AU - Maryam Ebrahimnia
AU - Mahsa Torkamanian-Afshar
AU - Yasaman Rezaee
AU - Sina Moayeri Jolandan
AU - Farnoosh Farahani
AU - Shahram Rabbani
AU - Azadeh Haeri
PY - 2026
DA - 2026/11/05
JO - Biomolecules
DO - 10.3390/biom16111614
UR - https://www.mdpi.com/2218-273X/16/11/1614
AB - Oral diseases have affected a large population worldwide. Phytochemicals have shown antioxidant, antibacterial, and anti-cancer properties, suggesting their potential for managing oral diseases. Conventional dosage forms containing phytochemicals are commercially available and have demonstrated promising effects in oral conditions. Recently, numerous phytochemical-based novel delivery systems (liposomes, niosomes, nanoparticles, nanofibers, hydrogels, etc.) have also been prepared to improve the efficacy of phytochemicals in managing the conditions discussed here. These novel delivery systems can improve local retention, protect phytochemicals from degradation, enhance penetration and bioavailability, and provide controlled or sustained release. This review therefore offers a delivery-system-focused perspective. Research articles from 2013 to 2026 were systematically reviewed. Preclinical and clinical applications of phenolic compounds (catechins, curcumin, quercetin, and resveratrol), carotenoids (lycopene, astaxanthin, and β-carotene), and alkaloids (berberine and piperine) for managing periodontal diseases, oral cancers, potentially malignant oral disorders, dental caries, oral candidiasis, and oral ulcers are summarized. The article provides an overview of oral diseases, classification, common phytochemicals, mechanisms, and clinical improvements. Finally, conventional and novel drug delivery systems loaded with phytochemicals are discussed. This work explores challenges and outlines future directions, with special attention to the role of artificial intelligence.
SN - 2218-273X
ER -