Peer-reviewedCC BY-NC-NDNeurology Genetics
The Association Between APOE Genotype, Race, and Dementia: An Analysis of 7 Population-Based Cohort Studies
Abstract
The apolipoprotein E (APOE) haplotypes are known to be associated with dementia, with the ε4 haplotype associated with higher risk. It has been suggested that the APOE ε2 allele serves as a protective factor for dementia. However, data on the effects of the homozygous APOE ε2/ε2 genotype are limited, likely due to the rarity of the APOE ε2/ε2 genotype. Furthermore, the association between APOE genotypes and dementia may differ across self-reported race. We aim to investigate the association between APOE genotypes and dementia overall and across self-reported race, with a focus on the potential protective effects of the ε2 haplotype and differences across race.
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BibTeX
@article{hughes2026association,
title = {{The Association Between APOE Genotype, Race, and Dementia: An Analysis of 7 Population-Based Cohort Studies}},
author = {Timothy M. Hughes and Vilmundur Guðnason and Michael Griswold and Paul S. De Vries and Alison Fohner and Pamela L. Lutsey and Rachel Zmora and Elizabeth A. Peterson and Denise Scholtens and Norrina B. Allen and Sanaz Sedaghat and Natalia Lakomski and Katherine Giorgio and John Stephen and Maxwell Mansolf and Aïcha Soumaré and Alden L. Gross and Allison E. Aiello and Archana Singh-Manoux and M. Arfan Ikram and Catherine Helmer and Claudia L. Satizabal and Deborah A. Levine and Donald M. Lloyd-Jones and Emily M. Briceño and Farzaneh A. Sorond and Frank J. Wolters and Jayandra J. Himali and Lenore J. Launer and Djass Mbangdadji and David Li and Lihui Zhao and Oscar L. Lopez and Stéphanie Debette and Sudha Seshadri and Suzanne E. Judd},
journal = {Neurology Genetics},
year = {2026},
month = sep,
doi = {10.1212/nxg.0000000000200417},
url = {https://hal.science/hal-05736253v1},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - The Association Between APOE Genotype, Race, and Dementia: An Analysis of 7 Population-Based Cohort Studies
AU - Timothy M. Hughes
AU - Vilmundur Guðnason
AU - Michael Griswold
AU - Paul S. De Vries
AU - Alison Fohner
AU - Pamela L. Lutsey
AU - Rachel Zmora
AU - Elizabeth A. Peterson
AU - Denise Scholtens
AU - Norrina B. Allen
AU - Sanaz Sedaghat
AU - Natalia Lakomski
AU - Katherine Giorgio
AU - John Stephen
AU - Maxwell Mansolf
AU - Aïcha Soumaré
AU - Alden L. Gross
AU - Allison E. Aiello
AU - Archana Singh-Manoux
AU - M. Arfan Ikram
AU - Catherine Helmer
AU - Claudia L. Satizabal
AU - Deborah A. Levine
AU - Donald M. Lloyd-Jones
AU - Emily M. Briceño
AU - Farzaneh A. Sorond
AU - Frank J. Wolters
AU - Jayandra J. Himali
AU - Lenore J. Launer
AU - Djass Mbangdadji
AU - David Li
AU - Lihui Zhao
AU - Oscar L. Lopez
AU - Stéphanie Debette
AU - Sudha Seshadri
AU - Suzanne E. Judd
PY - 2026
DA - 2026/09/02
JO - Neurology Genetics
DO - 10.1212/nxg.0000000000200417
UR - https://hal.science/hal-05736253v1
AB - The apolipoprotein E (APOE) haplotypes are known to be associated with dementia, with the ε4 haplotype associated with higher risk. It has been suggested that the APOE ε2 allele serves as a protective factor for dementia. However, data on the effects of the homozygous APOE ε2/ε2 genotype are limited, likely due to the rarity of the APOE ε2/ε2 genotype. Furthermore, the association between APOE genotypes and dementia may differ across self-reported race. We aim to investigate the association between APOE genotypes and dementia overall and across self-reported race, with a focus on the potential protective effects of the ε2 haplotype and differences across race.
SN - 2376-7839
ER -