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Peer-reviewedCC BY-NC-NDStem cell research & therapy

MRI-based mesenchymal stem cells: a theragnostic approach to fibrosis.

  • Yiqi Pan1,2
  • Yuanyuan Bao3
  • Yanbing Bao3
  • Mengyi Yang3
  • Yuanyuan Xie4
  • Xiaoli Mai5,6
6 affiliations
  1. 1Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Gulou District, Zhongshan Road 321, Nanjing, 210008, Jiangsu, China.
  2. 2Department of Radiology, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine, Chinese Academy of Sciences, Hangzhou, 310022, China.
  3. 3Department of Radiology, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, 210008, China.
  4. 4Clinical Stem Cell Center, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210008, China.
  5. 5Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Gulou District, Zhongshan Road 321, Nanjing, 210008, Jiangsu, China. [email protected].
  6. 6Department of Radiology, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, 210008, China. [email protected].
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Abstract

Fibrosis is a pathological process characterized by excessive deposition of extracellular matrix (ECM), severely impairing organ function. Mesenchymal stem cells (MSCs) have been extensively utilized in the treatment of fibrotic diseases, owing to their distinctive biological characteristics. Nevertheless, challenges persist in the long-term tracking of MSCs and the assessment of therapeutic efficacy during treatment. Non-invasive detection techniques for MSCs during disease therapy, achieved through the synergistic use of magnetic resonance imaging (MRI) and contrast agents, are increasingly mature. This paper outlines the classification, labelling methods, imaging advantages, and comprehensive evaluation of MSCs as MRI molecular probes in fibrotic disease treatment, while exploring their current status and future prospects.

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Cite

BibTeXRIS
BibTeX
@article{pan2026mribased,
  title = {{MRI-based mesenchymal stem cells: a theragnostic approach to fibrosis.}},
  author = {Yiqi Pan and Yuanyuan Bao and Yanbing Bao and Mengyi Yang and Yuanyuan Xie and Xiaoli Mai},
  journal = {Stem cell research \& therapy},
  year = {2026},
  month = aug,
  doi = {10.1186/s13287-026-05210-2},
  url = {https://europepmc.org/article/MED/42972603},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - MRI-based mesenchymal stem cells: a theragnostic approach to fibrosis.
AU  - Yiqi Pan
AU  - Yuanyuan Bao
AU  - Yanbing Bao
AU  - Mengyi Yang
AU  - Yuanyuan Xie
AU  - Xiaoli Mai
PY  - 2026
DA  - 2026/08/06
JO  - Stem cell research & therapy
DO  - 10.1186/s13287-026-05210-2
UR  - https://europepmc.org/article/MED/42972603
AB  - Fibrosis is a pathological process characterized by excessive deposition of extracellular matrix (ECM), severely impairing organ function. Mesenchymal stem cells (MSCs) have been extensively utilized in the treatment of fibrotic diseases, owing to their distinctive biological characteristics. Nevertheless, challenges persist in the long-term tracking of MSCs and the assessment of therapeutic efficacy during treatment. Non-invasive detection techniques for MSCs during disease therapy, achieved through the synergistic use of magnetic resonance imaging (MRI) and contrast agents, are increasingly mature. This paper outlines the classification, labelling methods, imaging advantages, and comprehensive evaluation of MSCs as MRI molecular probes in fibrotic disease treatment, while exploring their current status and future prospects.
SN  - 1757-6512
ER  -