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Peer-reviewedCC BY 4.0Advanced Science

A pH‐Switchable Cerium Single‐Atom Enzyme for Peri‐Implantitis Therapy via JAK‐STAT Signaling Axis‐Mediated Macrophage Reprogramming

  • Xiaomin Xia1,2
  • Haojie Wu3
  • Xingyun Li3
  • Lining Liu3
  • Kaiqing Song1,2
  • Jinpei Cui1,2
  • Jie Liu1,2
  • Jiaxuan Yin3
  • Emtiaz Ahmed4
  • Yusuke Yamauchi4,5
  • Xue Li1,2
5 affiliations
  1. 1Department of Stomatology The Affiliated Hospital of Qingdao University Qingdao University Qingdao China
  2. 2School of Stomatology Qingdao University Qingdao China
  3. 3Institute of Materials for Energy and Environment College of Materials Science and Engineering Qingdao University Qingdao China
  4. 4Australian Institute for Bioengineering and Nanotechnology (AIBN) The University of Queensland Brisbane Queensland Australia
  5. 5Department of Materials Process Engineering Graduate School of Engineering Nagoya University Nagoya Japan
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Abstract

The development of high‐performance, environmentally adaptive enzyme‐mimicking catalysts for the treatment of peri‐implantitis (PI) is of great importance yet remains highly challenging. Herein, we report a high‐performance cerium single atom on B, N co‐doped carbon nanotubes enzyme (SAzyme), denoted as Ce‐BNC. Benefitting from its unique N/O‐coordinated electronic environment and reversible Ce3+/Ce4+ redox cycle, Ce‐BNC exhibits an intrinsic pH‐switchable catalytic function, with acidic conditions favoring peroxidase (POD)‐likeactivity for hydrogen peroxide (H2O2) activation and reactive oxygen species (ROS)‐mediated antibacterial effects, whereas relatively neutral conditions promote superoxide dismutase (SOD)‐ and catalase (CAT)‐like enzymatic cascades for ROS conversion and oxygen generation. Through this pH‐switchable catalytic transition, Ce‐BNC enables dynamic switching between oxidative antimicrobial activity and antioxidative microenvironment modulation. Mechanistically, this pH‐switchable enzymatic relay is thermodynamically governed by reduced Gibbs free‐energy barriers. This antioxidant effect further disrupts the M1 macrophage/IL‐6‐JAK/STAT signaling axis, thereby remodeling the inflammatory microenvironment. This work presents a microenvironment‐adaptive catalytic platform with programmable bimodal activities, offering a promising paradigm for the intelligent and staged treatment of inflammatory diseases.

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Cite

BibTeXRIS
BibTeX
@article{xia2026phswitchable,
  title = {{A pH‐Switchable Cerium Single‐Atom Enzyme for Peri‐Implantitis Therapy via JAK‐STAT Signaling Axis‐Mediated Macrophage Reprogramming}},
  author = {Xiaomin Xia and Haojie Wu and Xingyun Li and Lining Liu and Kaiqing Song and Jinpei Cui and Jie Liu and Jiaxuan Yin and Emtiaz Ahmed and Yusuke Yamauchi and Xue Li},
  journal = {Advanced Science},
  year = {2026},
  month = aug,
  doi = {10.1002/advs.77002},
  url = {https://doi.org/10.1002/advs.77002},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - A pH‐Switchable Cerium Single‐Atom Enzyme for Peri‐Implantitis Therapy via JAK‐STAT Signaling Axis‐Mediated Macrophage Reprogramming
AU  - Xiaomin Xia
AU  - Haojie Wu
AU  - Xingyun Li
AU  - Lining Liu
AU  - Kaiqing Song
AU  - Jinpei Cui
AU  - Jie Liu
AU  - Jiaxuan Yin
AU  - Emtiaz Ahmed
AU  - Yusuke Yamauchi
AU  - Xue Li
PY  - 2026
DA  - 2026/08/12
JO  - Advanced Science
DO  - 10.1002/advs.77002
UR  - https://doi.org/10.1002/advs.77002
AB  - The development of high‐performance, environmentally adaptive enzyme‐mimicking catalysts for the treatment of peri‐implantitis (PI) is of great importance yet remains highly challenging. Herein, we report a high‐performance cerium single atom on B, N co‐doped carbon nanotubes enzyme (SAzyme), denoted as Ce‐BNC. Benefitting from its unique N/O‐coordinated electronic environment and reversible Ce3+/Ce4+ redox cycle, Ce‐BNC exhibits an intrinsic pH‐switchable catalytic function, with acidic conditions favoring peroxidase (POD)‐likeactivity for hydrogen peroxide (H2O2) activation and reactive oxygen species (ROS)‐mediated antibacterial effects, whereas relatively neutral conditions promote superoxide dismutase (SOD)‐ and catalase (CAT)‐like enzymatic cascades for ROS conversion and oxygen generation. Through this pH‐switchable catalytic transition, Ce‐BNC enables dynamic switching between oxidative antimicrobial activity and antioxidative microenvironment modulation. Mechanistically, this pH‐switchable enzymatic relay is thermodynamically governed by reduced Gibbs free‐energy barriers. This antioxidant effect further disrupts the M1 macrophage/IL‐6‐JAK/STAT signaling axis, thereby remodeling the inflammatory microenvironment. This work presents a microenvironment‐adaptive catalytic platform with programmable bimodal activities, offering a promising paradigm for the intelligent and staged treatment of inflammatory diseases.
SN  - 2198-3844
ER  -