A novel foam-board-based plasmonic chemosensor towards specific recognition of formaldehyde and acetaldehyde using silver nanoprism reinforced by 1,10-phenanthroline and d-penicillamine: construction of a miniaturized optical device by 3D printer towards rapid pharmaceutical analysis.
- 1Nutrition Research Center, Tabriz University of Medical Sciences Tabriz Iran.
- 2Pharmaceutical Analysis Research Center, Pharmaceutical Science Institute, Tabriz University of Medical Sciences Tabriz Iran [email protected].
- 3Department of Nanotechnology, Faculty of Chemistry, Urmia University Urmia Iran.
Abstract
Formaldehyde (FA) and acetaldehyde (AA) are highly reactive aldehydes that widely distributed in environmental matrices. Due to their potential toxicity and adverse health effects, the development of sensitive, selective, methods for their determination are of significant importance. But, quantification of FA and AA by conventional method require expensive instruments, sample preparation steps, export operators which load to limitation of its application for on-site analysis of volatile organic compounds (VOCs). In this study, a novel plasmonic colorimetric sensing device based on foam-board decorated by silver nanoprisms (AgNPrs) reinforced by with 1,10 phenanthroline (OFA) and d-penicillamine (DPA) was developed for the selective detection of FA and AA. The sensing mechanism relies on analyte-induced modulation of the localized surface plasmon resonance (LSPR) characteristics of AgNPrs, resulting in distinct colorimetric responses that can be visually observed and quantitatively analyzed using smartphone-assisted digital image processing. Quantitative analysis was performed using RGB histogram analysis, providing reliable FA and AA sensor in low volume of analyte and optional probe without the need for laboratory instrumentation. Under optimized conditions, the proposed photo-sensing platform exhibited a dynamic linear detection range of 1 to 200 µM for both FA and AA. The analytical capability of the developed sensing strategy was further validated in human urine samples, demonstrating reliable performance in complex biological matrices. The integration of plasmonic AgNPrs, selective ligand (DPA and OFA), smartphone-assisted image, and a flexible miniaturized sensing substrate provides a simple, low-cost, and portable colorimetric chemosensor for aldehyde monitoring in real samples. The proposed chemosensor shows a novel strategy for on-site recognition of VOCs.
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BibTeX
@article{bahavarnia2026novel,
title = {{A novel foam-board-based plasmonic chemosensor towards specific recognition of formaldehyde and acetaldehyde using silver nanoprism reinforced by 1,10-phenanthroline and d-penicillamine: construction of a miniaturized optical device by 3D printer towards rapid pharmaceutical analysis.}},
author = {Farnaz Bahavarnia and Mohammad Hasanzadeh and Nasrin Shadjou},
journal = {RSC advances},
year = {2026},
month = oct,
doi = {10.1039/d6ra07451k},
url = {https://europepmc.org/article/MED/42948387},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - A novel foam-board-based plasmonic chemosensor towards specific recognition of formaldehyde and acetaldehyde using silver nanoprism reinforced by 1,10-phenanthroline and d-penicillamine: construction of a miniaturized optical device by 3D printer towards rapid pharmaceutical analysis.
AU - Farnaz Bahavarnia
AU - Mohammad Hasanzadeh
AU - Nasrin Shadjou
PY - 2026
DA - 2026/10/27
JO - RSC advances
DO - 10.1039/d6ra07451k
UR - https://europepmc.org/article/MED/42948387
AB - Formaldehyde (FA) and acetaldehyde (AA) are highly reactive aldehydes that widely distributed in environmental matrices. Due to their potential toxicity and adverse health effects, the development of sensitive, selective, methods for their determination are of significant importance. But, quantification of FA and AA by conventional method require expensive instruments, sample preparation steps, export operators which load to limitation of its application for on-site analysis of volatile organic compounds (VOCs). In this study, a novel plasmonic colorimetric sensing device based on foam-board decorated by silver nanoprisms (AgNPrs) reinforced by with 1,10 phenanthroline (OFA) and d-penicillamine (DPA) was developed for the selective detection of FA and AA. The sensing mechanism relies on analyte-induced modulation of the localized surface plasmon resonance (LSPR) characteristics of AgNPrs, resulting in distinct colorimetric responses that can be visually observed and quantitatively analyzed using smartphone-assisted digital image processing. Quantitative analysis was performed using RGB histogram analysis, providing reliable FA and AA sensor in low volume of analyte and optional probe without the need for laboratory instrumentation. Under optimized conditions, the proposed photo-sensing platform exhibited a dynamic linear detection range of 1 to 200 µM for both FA and AA. The analytical capability of the developed sensing strategy was further validated in human urine samples, demonstrating reliable performance in complex biological matrices. The integration of plasmonic AgNPrs, selective ligand (DPA and OFA), smartphone-assisted image, and a flexible miniaturized sensing substrate provides a simple, low-cost, and portable colorimetric chemosensor for aldehyde monitoring in real samples. The proposed chemosensor shows a novel strategy for on-site recognition of VOCs.
SN - 2046-2069
ER -