Skip to content
DraconiticResearch
Search Sources API
190,332 studies31 sourcesUpdated 16 min ago
Peer-reviewedCC BYImmunometabolism (Cobham, Surrey)

Macrophage peroxisomes at the crossroads of inflammation.

  • Abhishek V Thakkar1
  • Irfan J Lodhi2
  • Edward B Thorp1,3
  1. 1Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.
  2. 2Division of Endocrinology, Metabolism and Lipid Research, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
  3. 3Heart Center, Lurie Children's Hospital, Chicago, IL, USA.
Read full textPDFDOICite

Abstract

Macrophage plasticity of function enables the control of inflammation and its resolution. This plasticity is calibrated by the coordination of cellular signaling with intracellular metabolism. Peroxisomes are regulators of lipid metabolism, and emerging discoveries implicate these organelles in both the control of inflammation and macrophage polarization. Herein, we summarize the immunomodulatory functions of macrophage peroxisomes, with a particular focus on the integration of lipid metabolism. Highlighted are the diverse fates of inflammation due to peroxisomal activity and peroxisomal targeting as an emerging concept for regulation of inflammation and inflammatory disorders.

Related

  1. PPARγ brakes cytosolic DNA-induced macrophage inflammation by super-enhancer metabolic reprogramming
    P. Meng, S. Zhang, X. Fan +9
    bioRxivPreprintAll rights reservedFull textImmunologybioRxiv
  2. Alternatively polarized neutrophils metabolically restrain macrophage-driven inflammation
    P. Ettel, J. L. Wilson, P. Saha +11
    bioRxivPreprintAll rights reservedFull textImmunologybioRxiv
  3. Targeting Macrophage Connexin 43 Hemichannels Suppresses Synovial Inflammation and Osteoarthritis
    R. Hua, Y. Tian, X. Wang +10
    bioRxivPreprintAll rights reservedFull textImmunologybioRxiv
  4. Acute respiratory distress syndrome FXR/Sptlc2 signaling promotes alveolar macrophage mitophagy and limits lung inflammation
    Mi Yan, Yanfei Liu, Mengsheng Deng +13
    Cell ReportsPeer-reviewedCC BY 4.0Full textGeneral biologyCrossrefDOAJ
  5. Macrophage efferocytosis in MASH: balancing inflammation resolution and fibrosis
    Qian Liu, Yongcheng Yang
    Frontiers in ImmunologyPeer-reviewedCC BY 4.0ImmunologyFrontiersCrossref

Cite

BibTeXRIS
BibTeX
@article{thakkar2026macrophage,
  title = {{Macrophage peroxisomes at the crossroads of inflammation.}},
  author = {Abhishek V Thakkar and Irfan J Lodhi and Edward B Thorp},
  journal = {Immunometabolism (Cobham, Surrey)},
  year = {2026},
  month = oct,
  doi = {10.1097/in9.0000000000000092},
  url = {https://europepmc.org/article/MED/42903971},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Macrophage peroxisomes at the crossroads of inflammation.
AU  - Abhishek V Thakkar
AU  - Irfan J Lodhi
AU  - Edward B Thorp
PY  - 2026
DA  - 2026/10/20
JO  - Immunometabolism (Cobham, Surrey)
DO  - 10.1097/in9.0000000000000092
UR  - https://europepmc.org/article/MED/42903971
AB  - Macrophage plasticity of function enables the control of inflammation and its resolution. This plasticity is calibrated by the coordination of cellular signaling with intracellular metabolism. Peroxisomes are regulators of lipid metabolism, and emerging discoveries implicate these organelles in both the control of inflammation and macrophage polarization. Herein, we summarize the immunomodulatory functions of macrophage peroxisomes, with a particular focus on the integration of lipid metabolism. Highlighted are the diverse fates of inflammation due to peroxisomal activity and peroxisomal targeting as an emerging concept for regulation of inflammation and inflammatory disorders.
SN  - 2633-0407
ER  -