PreprintAll rights reservedbioRxiv
Resistance-Mutant Rescue Establishes On-Target CHI3L1 Inhibition by CHI-DEL, a Brain-Penetrant Small Molecule with In Vivo Efficacy in Glioblastoma
- 1Columbia University Irving Medical Center
Related
- Reversing the Hypoxic Adaptive Response in Breast Cancer Cells through Small-Molecule Inhibition of Oncogenic MicroRNA-210
- GSC State Plasticity Drives Therapeutic Resistance and Recurrence in Glioblastoma
- Peptide-mediated inhibition of aberrant chaperone-mediated autophagy in pericytes prevents glioblastoma progression through MAPT/tau secretion
- MALT1 protease inhibition restrains glioblastoma progression by reversing tumor-associated macrophage-dependent immunosuppression in mice
- Methyl jasmonate (MeJA) as an elicitor enhances tomato resistance through ROS and digestive enzyme inhibition against Helicoverpa armigera (Lepidoptera: Noctuidae)
BibTeX
@misc{upadhyay2026resistancemutant,
title = {{Resistance-Mutant Rescue Establishes On-Target CHI3L1 Inhibition by CHI-DEL, a Brain-Penetrant Small Molecule with In Vivo Efficacy in Glioblastoma}},
author = {S. Upadhyay and L. Zhang and M. Teplova and S. Khan and M. Gabr},
howpublished = {bioRxiv},
year = {2026},
month = oct,
doi = {10.64898/2026.10.20.760326},
url = {https://www.biorxiv.org/content/10.64898/2026.10.20.760326v1},
}
RIS
TY - UNPB
TI - Resistance-Mutant Rescue Establishes On-Target CHI3L1 Inhibition by CHI-DEL, a Brain-Penetrant Small Molecule with In Vivo Efficacy in Glioblastoma
AU - S. Upadhyay
AU - L. Zhang
AU - M. Teplova
AU - S. Khan
AU - M. Gabr
PY - 2026
DA - 2026/10/20
PB - bioRxiv
DO - 10.64898/2026.10.20.760326
UR - https://www.biorxiv.org/content/10.64898/2026.10.20.760326v1
ER -