Right Place, Right Function: The Contribution of Subcellular Localization to the Physiological Impact of TRPM2 Channels.
- 1Univ. Lille, Inserm, CHU Lille, CNRS, U1366-UMR9020-CRCLille-Cancer Research Center of Lille, F-59000 Lille, France.
Abstract
The channel TRPM2 forms cation-selective channels and is activated by redox-dynamics, including oxidative stress. Initially described at the plasma membrane, TRPM2 has been found to also localized to intracellular compartments, i.e., nucleus, mitochondria, lysosomes, and the endoplasmic reticulum. Its subcellular distribution appears to influence the Ca²⁺ signals and signaling pathways associated with each compartment, resulting in distinct cellular outcomes. In cancer, TRPM2 has been implicated in proliferation, survival, autophagy, mitochondrial homeostasis, metabolism, inflammation, and cell death. Notably, TRPM2 can exert opposing effects depending on the cellular context, oxidative state, stimulus, and subcellular localization. These findings suggest that the functional diversity of TRPM2 may arise, at least in part, from its spatial organization within the cell.
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BibTeX
@article{hasselsweiller2026right,
title = {{Right Place, Right Function: The Contribution of Subcellular Localization to the Physiological Impact of TRPM2 Channels.}},
author = {Alice Hasselsweiller and Bich-Thi Camille Nguyen and Mayar Soussi and Dimitra Gkika},
journal = {Life (Basel, Switzerland)},
year = {2026},
month = oct,
doi = {10.3390/life16101761},
url = {https://europepmc.org/article/MED/42942347},
note = {CC BY},
}
RIS
TY - JOUR
TI - Right Place, Right Function: The Contribution of Subcellular Localization to the Physiological Impact of TRPM2 Channels.
AU - Alice Hasselsweiller
AU - Bich-Thi Camille Nguyen
AU - Mayar Soussi
AU - Dimitra Gkika
PY - 2026
DA - 2026/10/21
JO - Life (Basel, Switzerland)
DO - 10.3390/life16101761
UR - https://europepmc.org/article/MED/42942347
AB - The channel TRPM2 forms cation-selective channels and is activated by redox-dynamics, including oxidative stress. Initially described at the plasma membrane, TRPM2 has been found to also localized to intracellular compartments, i.e., nucleus, mitochondria, lysosomes, and the endoplasmic reticulum. Its subcellular distribution appears to influence the Ca²⁺ signals and signaling pathways associated with each compartment, resulting in distinct cellular outcomes. In cancer, TRPM2 has been implicated in proliferation, survival, autophagy, mitochondrial homeostasis, metabolism, inflammation, and cell death. Notably, TRPM2 can exert opposing effects depending on the cellular context, oxidative state, stimulus, and subcellular localization. These findings suggest that the functional diversity of TRPM2 may arise, at least in part, from its spatial organization within the cell.
SN - 2075-1729
ER -