Peer-reviewedCC BYmicroPublication Biology
High confidence HIF-1 target genes for quantifying the activation of the HIF-1-mediated hypoxia response
- 1Neurology and Neurosurgery, McGill University, Montreal, QC, Canada
- 2Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada
Abstract
The hypoxia-inducible factor 1 (HIF-1)-mediated hypoxia response is an evolutionarily conserved stress response that enables adaptation to conditions of low oxygen and mitochondrial dysfunction. This pathway has been shown to affect both stress resistance and longevity. HIF-1 activity is regulated by EGL-9, VHL-1, and RHY-1 and induces the expression of genes involved in metabolism and cellular resilience. To find genes that can be used to monitor HIF-1 activation, we compared HIF-1 modulated genes identified by multiple RNA-seq experiments and HIF-1 target genes identified by ChIP-seq experiments. We identified high-confidence HIF-1 target genes that provide robust markers of pathway activation.
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BibTeX
@article{desnos2026high,
title = {{High confidence HIF-1 target genes for quantifying the activation of the HIF-1-mediated hypoxia response}},
author = {Camille AH Desnos and Aura A Tamez Gonzalez and Jeremy M Van Raamsdonk},
journal = {microPublication Biology},
year = {2026},
month = sep,
doi = {10.17912/micropub.biology.002304},
url = {https://doi.org/10.17912/micropub.biology.002304},
note = {CC BY},
}
RIS
TY - JOUR
TI - High confidence HIF-1 target genes for quantifying the activation of the HIF-1-mediated hypoxia response
AU - Camille AH Desnos
AU - Aura A Tamez Gonzalez
AU - Jeremy M Van Raamsdonk
PY - 2026
DA - 2026/09/01
JO - microPublication Biology
DO - 10.17912/micropub.biology.002304
UR - https://doi.org/10.17912/micropub.biology.002304
AB - The hypoxia-inducible factor 1 (HIF-1)-mediated hypoxia response is an evolutionarily conserved stress response that enables adaptation to conditions of low oxygen and mitochondrial dysfunction. This pathway has been shown to affect both stress resistance and longevity. HIF-1 activity is regulated by EGL-9, VHL-1, and RHY-1 and induces the expression of genes involved in metabolism and cellular resilience. To find genes that can be used to monitor HIF-1 activation, we compared HIF-1 modulated genes identified by multiple RNA-seq experiments and HIF-1 target genes identified by ChIP-seq experiments. We identified high-confidence HIF-1 target genes that provide robust markers of pathway activation.
SN - 2578-9430
ER -