Skip to content
DraconiticResearch
Search Sources API
203,234 studies31 sourcesUpdated 9 min ago
Peer-reviewedCC BY-NCRNA biology

The architectural and functional landscape of transposon-derived chimeric RNAs.

  • Yangquan Xiang1,2
  • Hongqing Liang1,2
  1. 1Institute of Medical Genetics and Development, Key Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
  2. 2Zhejiang Provincial Birth Defect Control and Prevention Research Center, and Zhejiang International Science and Technology Cooperation Base of Reproductive Health, Hangzhou, China.
Read full textPDFDOICite

Abstract

This review systematically examines the architectural and functional landscape of transposable element (TE)-derived chimeric RNAs, classifying them into three major categories: TE-coding gene chimeras, TE-lncRNA chimeras and TE-TE chimeras. We delineate four potential molecular mechanisms contributing to their biogenesis: transcriptional read-through coupled with cis-splicing, promoter hijacking by TE-derived regulatory elements, trans-splicing of independent transcripts and epigenetic regulation of TE genomic loci. Functionally, TE and their chimeric RNAs can coordinately participate in genomic regulation at different levels: they remodel native gene expression patterns via alternative promoters, introduce novel functional domains into proteins and lncRNAs, and form integrated transcriptional regulatory networks. These chimeric transcripts exert critical roles in early embryonic development, stem cell potency, differentiation or pathogenic condition. Looking forward, long-read sequencing and genomic targeting technologies hold great promise to unravel the functionality and therapeutic application of TE-derived chimeric RNAs. Collectively, this review establishes TE-derived chimeric RNAs as fundamental drivers of transcriptomic innovation, evolutionary adaptation and disease aetiology, bridging basic genome biology with physiology and clinical translation.

Related

  1. A functional atlas of transposon-encoded products and their integration into host networks
    Carles Borredá, Pol Vendrell‐Mir, Basile Leduque +5
    Nature CommunicationsPeer-reviewedCC BY-NC-ND8 citedPlant biologyOpenAlex
  2. Argonaute 15 regulates immunity of potato to filamentous pathogens through transposon-derived small RNAs
    S. Singh, X. Hu, Z. Liao +2
    bioRxivPreprintCC BYFull textPlant biologybioRxiv
  3. Targeting Cardiac Fibrosis with Chimeric Antigen Receptor Neutrophils Derived from Human Pluripotent Stem Cells
    G. Jin, S. Fang, Y. Chang +7
    bioRxivPreprintCC BYFull textSystems & synthetic biologybioRxiv
  4. Cancer-inspired, chimeric microparticles drive differential modulation of bone marrow-derived dendritic cells and potentiate diverse polarization in T cells
    Gaddam Krishna, Allen B. Tu, Reuben Abraham +3
    Materials AdvancesPeer-reviewedCC BY-NC 3.0Full textImmunologyPMCEurope PMC
  5. Genome-resolved metagenomics reveals the taxonomic and functional landscape of the rumen microbiome in Japanese Black × Holstein cattle and its associations with carcass traits
    Yoshiaki Sato
    BMC GenomicsPeer-reviewedCC BY-NC-ND 4.0Plant biologyCrossref

Cite

BibTeXRIS
BibTeX
@article{xiang2026architectural,
  title = {{The architectural and functional landscape of transposon-derived chimeric RNAs.}},
  author = {Yangquan Xiang and Hongqing Liang},
  journal = {RNA biology},
  year = {2026},
  month = oct,
  doi = {10.1080/15476286.2026.2743461},
  url = {https://europepmc.org/article/MED/42902538},
  note = {CC BY-NC},
}
RIS
TY  - JOUR
TI  - The architectural and functional landscape of transposon-derived chimeric RNAs.
AU  - Yangquan Xiang
AU  - Hongqing Liang
PY  - 2026
DA  - 2026/10/20
JO  - RNA biology
DO  - 10.1080/15476286.2026.2743461
UR  - https://europepmc.org/article/MED/42902538
AB  - This review systematically examines the architectural and functional landscape of transposable element (TE)-derived chimeric RNAs, classifying them into three major categories: TE-coding gene chimeras, TE-lncRNA chimeras and TE-TE chimeras. We delineate four potential molecular mechanisms contributing to their biogenesis: transcriptional read-through coupled with cis-splicing, promoter hijacking by TE-derived regulatory elements, trans-splicing of independent transcripts and epigenetic regulation of TE genomic loci. Functionally, TE and their chimeric RNAs can coordinately participate in genomic regulation at different levels: they remodel native gene expression patterns via alternative promoters, introduce novel functional domains into proteins and lncRNAs, and form integrated transcriptional regulatory networks. These chimeric transcripts exert critical roles in early embryonic development, stem cell potency, differentiation or pathogenic condition. Looking forward, long-read sequencing and genomic targeting technologies hold great promise to unravel the functionality and therapeutic application of TE-derived chimeric RNAs. Collectively, this review establishes TE-derived chimeric RNAs as fundamental drivers of transcriptomic innovation, evolutionary adaptation and disease aetiology, bridging basic genome biology with physiology and clinical translation.
SN  - 1547-6286
SN  - 1555-8584
ER  -