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Peer-reviewedCC BY 4.0Frontiers in Immunology

Post-translational modifications in rosacea

  • Xuting Zhang1
  • Hang Su2
  • Wanying Deng3
  • Fanghua Liu4
  • Shougang Liu5
5 affiliations
  1. 1Panyu Hospital of Traditional Chinese Medicine
  2. 2The Eighth Affiliated Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan)
  3. 3The First Affiliated Hospital of Guangdong Pharmaceutical University
  4. 4Ganzhou Municipal Hospital
  5. 5Dermatology Hospital of Southern Medical University
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Abstract

Rosacea is a chronic inflammatory skin disease that primarily affects the central facial region, including the cheeks, nose, chin, and forehead. Its clinical features include episodic flushing, persistent erythema, telangiectasia, papulopustular lesions, and in severe cases, phymatous changes such as rhinophyma. Rosacea substantially impairs patients’ quality of life, while current treatments focus primarily on symptom control. The pathogenesis of this disease involves abnormal immune responses, infiltration of immune cells, inflammatory reactions and angiogenesis, etc. Post-translational modifications (PTMs), particularly phosphorylation and ubiquitination, may play a role in initiating and sustaining these processes. This article reviews how PTMs such as phosphorylation and ubiquitination affect the pathogenesis of rosacea and assesses these PTM-regulated pathways as potential therapeutic targets.

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Cite

BibTeXRIS
BibTeX
@article{zhang2026posttranslational,
  title = {{Post-translational modifications in rosacea}},
  author = {Xuting Zhang and Hang Su and Wanying Deng and Fanghua Liu and Shougang Liu},
  journal = {Frontiers in Immunology},
  year = {2026},
  month = oct,
  doi = {10.3389/fimmu.2026.1931025},
  url = {https://www.frontiersin.org/articles/10.3389/fimmu.2026.1931025/full},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Post-translational modifications in rosacea
AU  - Xuting Zhang
AU  - Hang Su
AU  - Wanying Deng
AU  - Fanghua Liu
AU  - Shougang Liu
PY  - 2026
DA  - 2026/10/09
JO  - Frontiers in Immunology
DO  - 10.3389/fimmu.2026.1931025
UR  - https://www.frontiersin.org/articles/10.3389/fimmu.2026.1931025/full
AB  - Rosacea is a chronic inflammatory skin disease that primarily affects the central facial region, including the cheeks, nose, chin, and forehead. Its clinical features include episodic flushing, persistent erythema, telangiectasia, papulopustular lesions, and in severe cases, phymatous changes such as rhinophyma. Rosacea substantially impairs patients’ quality of life, while current treatments focus primarily on symptom control. The pathogenesis of this disease involves abnormal immune responses, infiltration of immune cells, inflammatory reactions and angiogenesis, etc. Post-translational modifications (PTMs), particularly phosphorylation and ubiquitination, may play a role in initiating and sustaining these processes. This article reviews how PTMs such as phosphorylation and ubiquitination affect the pathogenesis of rosacea and assesses these PTM-regulated pathways as potential therapeutic targets.
SN  - 1664-3224
ER  -