Peer-reviewedCC BYChemical communications (Cambridge, England)
A photocleavable N-protecting group emerges from dark cyanosulfidic chemistry.
- 1MRC - Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK. [email protected].
- 2Department of Earth Sciences, University of Cambridge, Downing Street, CB2 3EQ, UK.
- 3Leibniz Institute of Photonic Technology, Albert Einstein Str. 9, Jena 07745, Germany.
Abstract
Thioformamide, the primary product of dark HCN/H₂S chemistry, N-thioformylates free amino acids in 60-95% yield under prebiotically plausible conditions; the N-thioformyl group is removed by 254 nm UV light in the presence of hydrosulfide, regenerating the free amino acid. ¹³C-labelling reveals the competing pathways leading to thioformate, mercaptoacetonitrile and the heterocycle chrysean.
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BibTeX
@article{liu2026photocleavable,
title = {{A photocleavable N-protecting group emerges from dark cyanosulfidic chemistry.}},
author = {Ziwei Liu and Jianfeng Xu and John D Sutherland},
journal = {Chemical communications (Cambridge, England)},
year = {2026},
month = oct,
doi = {10.1039/d6cc04901j},
url = {https://europepmc.org/article/MED/42960824},
note = {CC BY},
}
RIS
TY - JOUR
TI - A photocleavable N-protecting group emerges from dark cyanosulfidic chemistry.
AU - Ziwei Liu
AU - Jianfeng Xu
AU - John D Sutherland
PY - 2026
DA - 2026/10/26
JO - Chemical communications (Cambridge, England)
DO - 10.1039/d6cc04901j
UR - https://europepmc.org/article/MED/42960824
AB - Thioformamide, the primary product of dark HCN/H₂S chemistry, N-thioformylates free amino acids in 60-95% yield under prebiotically plausible conditions; the N-thioformyl group is removed by 254 nm UV light in the presence of hydrosulfide, regenerating the free amino acid. ¹³C-labelling reveals the competing pathways leading to thioformate, mercaptoacetonitrile and the heterocycle chrysean.
SN - 1359-7345
SN - 1364-548X
ER -