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Peer-reviewedCC BY-NC-NDRespirology case reports

The Blind Spot of GeneXpert MTB/RIF: Isoniazid‐Resistant, Rifampicin‐Susceptible Tuberculosis Detected on Phenotypic Drug Susceptibility Testing

  • Hafiz Muhammad Faisal Nadeem1
  • Ali Gohar1
  • Muhammad Faisal Jakhar2
  • Rabbia Abbas1
  • Taqdees Noor3
  • Muhammad Husnain Ahmad4
4 affiliations
  1. 1Department of Pulmonology and Sleep Medicine Lahore General Hospital Lahore Punjab Pakistan.
  2. 2Department of Medicine Faisalabad Medical University Faisalabad Punjab Pakistan.
  3. 3Ameer-ud-Din Medical College, PGMI, Lahore General Hospital Lahore Punjab Pakistan.
  4. 4S Tentishev Asian Medical Institute Kant Kyrgyzstan.
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Abstract

GeneXpert MTB/RIF detects only rifampicin resistance. A 19-year-old man with cough and haemoptysis had rifampicin-susceptible tuberculosis on bronchoalveolar lavage Xpert. Phenotypic drug susceptibility testing later revealed isolated isoniazid resistance, and isoniazid was replaced with levofloxacin. Additional susceptibility testing is essential to detect isoniazid-resistant, rifampicin-susceptible tuberculosis.

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Cite

BibTeXRIS
BibTeX
@article{nadeem2026blind,
  title = {{The Blind Spot of GeneXpert MTB/RIF: Isoniazid‐Resistant, Rifampicin‐Susceptible Tuberculosis Detected on Phenotypic Drug Susceptibility Testing}},
  author = {Hafiz Muhammad Faisal Nadeem and Ali Gohar and Muhammad Faisal Jakhar and Rabbia Abbas and Taqdees Noor and Muhammad Husnain Ahmad},
  journal = {Respirology case reports},
  year = {2026},
  month = oct,
  doi = {10.1002/rcr2.70799},
  url = {https://europepmc.org/article/PMC/PMC13716936},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - The Blind Spot of GeneXpert MTB/RIF: Isoniazid‐Resistant, Rifampicin‐Susceptible Tuberculosis Detected on Phenotypic Drug Susceptibility Testing
AU  - Hafiz Muhammad Faisal Nadeem
AU  - Ali Gohar
AU  - Muhammad Faisal Jakhar
AU  - Rabbia Abbas
AU  - Taqdees Noor
AU  - Muhammad Husnain Ahmad
PY  - 2026
DA  - 2026/10/28
JO  - Respirology case reports
DO  - 10.1002/rcr2.70799
UR  - https://europepmc.org/article/PMC/PMC13716936
AB  - GeneXpert MTB/RIF detects only rifampicin resistance. A 19-year-old man with cough and haemoptysis had rifampicin-susceptible tuberculosis on bronchoalveolar lavage Xpert. Phenotypic drug susceptibility testing later revealed isolated isoniazid resistance, and isoniazid was replaced with levofloxacin. Additional susceptibility testing is essential to detect isoniazid-resistant, rifampicin-susceptible tuberculosis.
SN  - 2051-3380
ER  -