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Peer-reviewedCC BY 4.0International Journal of Molecular Sciences

Genome-Wide Identification and Expression Analysis of the HDAC Gene Family in Stevia rebaudiana

  • Chaoyong Zhao1,2,3
  • Yaning Fu1
  • Daiqi Wang4
  • Kai Lin4
  • Lingling Yun1
  • Fen Xie1
  • Genxiang Bai2,4
4 affiliations
  1. 1Beijing Life Science Academy, Beijing 102206, China
  2. 2Hubei Shizhen Laboratory, School of Basic Medical Sciences, Hubei University of Chinese Medicine, Wuhan 430065, China
  3. 3College of Agriculture, South China Agricultural University, Guangzhou 510642, China
  4. 4South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China
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Abstract

Histone deacetylases (HDACs) are crucial epigenetic regulators that modulate chromatin structure and gene expression through histone deacetylation. Stevia rebaudiana, a natural source of high-intensity sweeteners, faces significant cultivation challenges due to environmental stresses such as osmotic stress and salinity. However, the HDAC gene family in S. rebaudiana remains largely uncharacterized. Here, we present the first genome-wide analysis of the HDAC family in S. rebaudiana, identifying 22 SrHDAC transcripts derived from 18 gene loci, which were classified into three subfamilies (RPD3/HDA1, SIR2, and HD2). Systematic characterization of gene structure, conserved domains, and promoter cis elements indicated their potential involvement in hormone signaling and abiotic stress regulation. Expression profiling revealed tissue-specific expression patterns and differential responses to methyl jasmonate (MeJA) treatment and PEG-induced osmotic stress. Subcellular localization of representative proteins in Nicotiana benthamiana leaf cells supported nucleolar-associated functions. These findings provide a foundation for understanding HDAC-mediated epigenetic regulation in S. rebaudiana growth, development, and stress adaptation, and identify candidate genes for future functional studies toward stress-tolerant cultivar improvement.

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Cite

BibTeXRIS
BibTeX
@article{zhao2026genomewide,
  title = {{Genome-Wide Identification and Expression Analysis of the HDAC Gene Family in Stevia rebaudiana}},
  author = {Chaoyong Zhao and Yaning Fu and Daiqi Wang and Kai Lin and Lingling Yun and Fen Xie and Genxiang Bai},
  journal = {International Journal of Molecular Sciences},
  year = {2026},
  month = oct,
  doi = {10.3390/ijms27209177},
  url = {https://www.mdpi.com/1422-0067/27/20/9177},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Genome-Wide Identification and Expression Analysis of the HDAC Gene Family in Stevia rebaudiana
AU  - Chaoyong Zhao
AU  - Yaning Fu
AU  - Daiqi Wang
AU  - Kai Lin
AU  - Lingling Yun
AU  - Fen Xie
AU  - Genxiang Bai
PY  - 2026
DA  - 2026/10/01
JO  - International Journal of Molecular Sciences
DO  - 10.3390/ijms27209177
UR  - https://www.mdpi.com/1422-0067/27/20/9177
AB  - Histone deacetylases (HDACs) are crucial epigenetic regulators that modulate chromatin structure and gene expression through histone deacetylation. Stevia rebaudiana, a natural source of high-intensity sweeteners, faces significant cultivation challenges due to environmental stresses such as osmotic stress and salinity. However, the HDAC gene family in S. rebaudiana remains largely uncharacterized. Here, we present the first genome-wide analysis of the HDAC family in S. rebaudiana, identifying 22 SrHDAC transcripts derived from 18 gene loci, which were classified into three subfamilies (RPD3/HDA1, SIR2, and HD2). Systematic characterization of gene structure, conserved domains, and promoter cis elements indicated their potential involvement in hormone signaling and abiotic stress regulation. Expression profiling revealed tissue-specific expression patterns and differential responses to methyl jasmonate (MeJA) treatment and PEG-induced osmotic stress. Subcellular localization of representative proteins in Nicotiana benthamiana leaf cells supported nucleolar-associated functions. These findings provide a foundation for understanding HDAC-mediated epigenetic regulation in S. rebaudiana growth, development, and stress adaptation, and identify candidate genes for future functional studies toward stress-tolerant cultivar improvement.
SN  - 1422-0067
ER  -