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Peer-reviewedCC BY-NC 4.0International Journal of Surgical Pathology

Tubulo-Squamous Vaginal Polyp: A Clinicopathologic Series with Literature Review

  • Bushra K. Al-Tarawneh1,2
  • Sadeq Islam1
  • M. Ruhul Quddus1
  • Kamaljeet Singh1
  1. 1Pathology and Laboratory Medicine, Women and Infants Hospital of Rhode Island, Warren Alpert Medical School of Brown University, Providence, RI, USA
  2. 2Pathology and Microbiology Department, Faculty of Medicine, Mutah University, AlKarak, Jordan
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Abstract

Tubulo-squamous polyp (TSP) of vagina is a rare, benign, upper vaginal lesion of postmenopausal women. The origin of TSP is unclear, and the lesion is hypothesized to be arising from misplaced prostate-like vaginal skene glands. We describe the clinical, histological and immunohistochemical features of 6 TSPs we encountered in our routine practice. Histologically, TSPs are characterized by mass-forming, submucosal, cystic metaplastic transitional-type epithelium and prostate-like glands. The histological and immunohistochemical findings in TSP are identical to Mullerian (cervical and vaginal) epithelial metaplastic changes described in a setting of exogenous testosterone exposure.

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Cite

BibTeXRIS
BibTeX
@article{altarawneh2026tubulosquamous,
  title = {{Tubulo-Squamous Vaginal Polyp: A Clinicopathologic Series with Literature Review}},
  author = {Bushra K. Al-Tarawneh and Sadeq Islam and M. Ruhul Quddus and Kamaljeet Singh},
  journal = {International Journal of Surgical Pathology},
  year = {2026},
  month = may,
  doi = {10.1177/10668969261448581},
  url = {https://doi.org/10.1177/10668969261448581},
  note = {CC BY-NC 4.0},
}
RIS
TY  - JOUR
TI  - Tubulo-Squamous Vaginal Polyp: A Clinicopathologic Series with Literature Review
AU  - Bushra K. Al-Tarawneh
AU  - Sadeq Islam
AU  - M. Ruhul Quddus
AU  - Kamaljeet Singh
PY  - 2026
DA  - 2026/05/30
JO  - International Journal of Surgical Pathology
DO  - 10.1177/10668969261448581
UR  - https://doi.org/10.1177/10668969261448581
AB  - Tubulo-squamous polyp (TSP) of vagina is a rare, benign, upper vaginal lesion of postmenopausal women. The origin of TSP is unclear, and the lesion is hypothesized to be arising from misplaced prostate-like vaginal skene glands. We describe the clinical, histological and immunohistochemical features of 6 TSPs we encountered in our routine practice. Histologically, TSPs are characterized by mass-forming, submucosal, cystic metaplastic transitional-type epithelium and prostate-like glands. The histological and immunohistochemical findings in TSP are identical to Mullerian (cervical and vaginal) epithelial metaplastic changes described in a setting of exogenous testosterone exposure.
SN  - 1066-8969
SN  - 1940-2465
ER  -