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Peer-reviewedCC BYFrontiers in pediatrics

Severe capillary leak syndrome caused by postnatal cytomegalovirus infection in a very preterm infant: a case report

  • Junchen Fang1
  • Xin Chen2
  • Tingting Li1
  • Liyuan Cao1
  • Li Ma1
  1. 1Department of Neonatology, Hebei Children’s Hospital , ,
  2. 2Hebei Clinical Medical Research Center for Children’s Health and Diseases , ,
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Abstract

Postnatal cytomegalovirus (pCMV) infection in very preterm infants may lead to severe adverse outcomes; however, capillary leak syndrome as a complication of CMV infection has rarely been reported in this population. This article reports a case of severe capillary leak syndrome (CLS) in a very preterm infant following postnatal CMV infection. Despite conventional treatments, including antiviral therapy, fluid management, and cardiopulmonary support, the infant's condition progressively worsened, with signs of progressive fluid overload and acute kidney injury (AKI). Following the initiation of continuous renal replacement therapy (CRRT), the infant's clinical status improved, leading to eventual cure and discharge. This case highlights severe CLS can be a major manifestation of pCMV infection in very preterm infants. In addition to traditional therapy, CRRT can serve as an effective treatment option.

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Cite

BibTeXRIS
BibTeX
@article{fang2026severe,
  title = {{Severe capillary leak syndrome caused by postnatal cytomegalovirus infection in a very preterm infant: a case report}},
  author = {Junchen Fang and Xin Chen and Tingting Li and Liyuan Cao and Li Ma},
  journal = {Frontiers in pediatrics},
  year = {2026},
  month = oct,
  doi = {10.3389/fped.2026.1895522},
  url = {https://europepmc.org/article/PMC/PMC13716748},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Severe capillary leak syndrome caused by postnatal cytomegalovirus infection in a very preterm infant: a case report
AU  - Junchen Fang
AU  - Xin Chen
AU  - Tingting Li
AU  - Liyuan Cao
AU  - Li Ma
PY  - 2026
DA  - 2026/10/15
JO  - Frontiers in pediatrics
DO  - 10.3389/fped.2026.1895522
UR  - https://europepmc.org/article/PMC/PMC13716748
AB  - Postnatal cytomegalovirus (pCMV) infection in very preterm infants may lead to severe adverse outcomes; however, capillary leak syndrome as a complication of CMV infection has rarely been reported in this population. This article reports a case of severe capillary leak syndrome (CLS) in a very preterm infant following postnatal CMV infection. Despite conventional treatments, including antiviral therapy, fluid management, and cardiopulmonary support, the infant's condition progressively worsened, with signs of progressive fluid overload and acute kidney injury (AKI). Following the initiation of continuous renal replacement therapy (CRRT), the infant's clinical status improved, leading to eventual cure and discharge. This case highlights severe CLS can be a major manifestation of pCMV infection in very preterm infants. In addition to traditional therapy, CRRT can serve as an effective treatment option.
SN  - 2296-2360
ER  -