Stress-induced immune dysfunction and fungal infections: Mechanisms linking psychoneuroimmunology to invasive aspergillosis
- 1Department of Medical Mycology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
Abstract
Contex: Stress-induced states, such as anxiety and depression, can disrupt the microbiota's normal regulation of fungal overgrowth.
Evidence Acquisition: We searched the PubMed database for studies reporting on criteria such as psychological stress, immune system dysregulation, and microbial infection susceptibility
Results: Of particular concern is the relationship between stress and susceptibility to microbial infections. Microbial infections complicated by systemic inflammatory responses represent a significant public health challenge. Furthermore, certain treatments for microbial infections, including antifungal therapy and surgery for invasive aspergillosis (IA), can induce side effects that may exacerbate stress and anxiety.
Conclusion: This review has elucidated how stress influences susceptibility to microbial infections, particularly IA. The findings suggest that effective stress management is important in preventing and treating microbial infections.
Related
- Invasive Aspergillosis Following Dengue: An Autopsy Case and Review of the Literature
- Early invasive aspergillosis after liver transplantation: a matched case–control analysis of clinical features and risk factors in a Chinese cohort
- Invasive Aspergillosis Complicating Severe COVID-19: Cumulative Incidence, Risk Factors, and Outcomes Between the First Wave of the Pandemic and Subsequent Waves, According to the ECMM/ISHAM Classification and a Local Case Assessment
- Machine learning-based risk prediction for invasive pulmonary aspergillosis in non-neutropenic intensive care unit patients, with an exploratory analysis of pathogen-related risk factors.
- Unclassifiable Invasive Pulmonary Aspergillosis in the Intensive Care Unit: Insights From a Multicenter, Retrospective Cohort Study in France (2022–2024)
BibTeX
@article{tavakoli2026stressinduced,
title = {{Stress-induced immune dysfunction and fungal infections: Mechanisms linking psychoneuroimmunology to invasive aspergillosis}},
author = {Mahin Tavakoli},
journal = {Archives of Advances in Biosciences},
year = {2026},
month = oct,
doi = {10.22037/aab.v17i1.52657},
url = {https://doi.org/10.22037/aab.v17i1.52657},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - Stress-induced immune dysfunction and fungal infections: Mechanisms linking psychoneuroimmunology to invasive aspergillosis
AU - Mahin Tavakoli
PY - 2026
DA - 2026/10/24
JO - Archives of Advances in Biosciences
DO - 10.22037/aab.v17i1.52657
UR - https://doi.org/10.22037/aab.v17i1.52657
AB - Contex: Stress-induced states, such as anxiety and depression, can disrupt the microbiota's normal regulation of fungal overgrowth. Evidence Acquisition: We searched the PubMed database for studies reporting on criteria such as psychological stress, immune system dysregulation, and microbial infection susceptibility Results: Of particular concern is the relationship between stress and susceptibility to microbial infections. Microbial infections complicated by systemic inflammatory responses represent a significant public health challenge. Furthermore, certain treatments for microbial infections, including antifungal therapy and surgery for invasive aspergillosis (IA), can induce side effects that may exacerbate stress and anxiety. Conclusion: This review has elucidated how stress influences susceptibility to microbial infections, particularly IA. The findings suggest that effective stress management is important in preventing and treating microbial infections.
SN - 2783-1264
ER -