Fifteen‐Year Outcomes of Bilateral Pallidal Stimulation in Isolated Generalized Dystonia: Characterization of Therapeutic Response and Emergence of Parkinsonism
Abstract
Background: Bilateral pallidal deep brain stimulation (GPi-DBS) is effective for dystonia. Long-term evolution of therapeutic benefit and emergence of parkinsonism have not been systematically characterized. Objectives: To assess 15-year dystonia outcomes and characterize parkinsonism after bilateral GPi-DBS. Methods: Dystonia severity and disability were evaluated at baseline,1, 3, and 15 years postoperatively with the Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS). Parkinsonism was assessed at last visit using the Movement Disorder Society-Unified Parkinson's Disease Rating Scale-Part III and freezing of gait (FoG) questionnaire. Results: Of 17 patients reassessed at 15 years, 41% maintained clinical benefit. Parkinsonism was observed in 94%, predominantly axial, with self-reported FoG in 67%. Higher baseline BFMDRS-Motor scores predicted last follow-up axial parkinsonism (R = 0.800, P < 0.001). Conclusions: Over 15 years, interindividual therapeutic benefit diverged while axial parkinsonism emerged in nearly all patients. These findings highlight the need for systematic long-term monitoring extending beyond dystonia control after GPi-DBS.
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BibTeX
@article{desjardins2026fifteenyear,
title = {{Fifteen‐Year Outcomes of Bilateral Pallidal Stimulation in Isolated Generalized Dystonia: Characterization of Therapeutic Response and Emergence of Parkinsonism}},
author = {Clément Desjardins and Cécilia Bonnet and Elena Moro and David Grabli and Valérie Fraix and Marie‐laure Welter and Laurent Vercueil and Soledad Navarro and Carine Karachi and Thibaud Charrier and Sylvie Raoul and Mathilde Guibourd de Luzinais and Emmanuel Cuny and Stéphan Chabardes and Pierre Burbaud and Dominique Guehl and Pascal Derkinderen and Marie Vidailhet},
journal = {Movement Disorders},
year = {2026},
month = sep,
doi = {10.1002/mds.70504},
url = {https://hal.sorbonne-universite.fr/hal-05737281v1},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Fifteen‐Year Outcomes of Bilateral Pallidal Stimulation in Isolated Generalized Dystonia: Characterization of Therapeutic Response and Emergence of Parkinsonism
AU - Clément Desjardins
AU - Cécilia Bonnet
AU - Elena Moro
AU - David Grabli
AU - Valérie Fraix
AU - Marie‐laure Welter
AU - Laurent Vercueil
AU - Soledad Navarro
AU - Carine Karachi
AU - Thibaud Charrier
AU - Sylvie Raoul
AU - Mathilde Guibourd de Luzinais
AU - Emmanuel Cuny
AU - Stéphan Chabardes
AU - Pierre Burbaud
AU - Dominique Guehl
AU - Pascal Derkinderen
AU - Marie Vidailhet
PY - 2026
DA - 2026/09/03
JO - Movement Disorders
DO - 10.1002/mds.70504
UR - https://hal.sorbonne-universite.fr/hal-05737281v1
AB - Background: Bilateral pallidal deep brain stimulation (GPi-DBS) is effective for dystonia. Long-term evolution of therapeutic benefit and emergence of parkinsonism have not been systematically characterized. Objectives: To assess 15-year dystonia outcomes and characterize parkinsonism after bilateral GPi-DBS. Methods: Dystonia severity and disability were evaluated at baseline,1, 3, and 15 years postoperatively with the Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS). Parkinsonism was assessed at last visit using the Movement Disorder Society-Unified Parkinson's Disease Rating Scale-Part III and freezing of gait (FoG) questionnaire. Results: Of 17 patients reassessed at 15 years, 41% maintained clinical benefit. Parkinsonism was observed in 94%, predominantly axial, with self-reported FoG in 67%. Higher baseline BFMDRS-Motor scores predicted last follow-up axial parkinsonism (R = 0.800, P < 0.001). Conclusions: Over 15 years, interindividual therapeutic benefit diverged while axial parkinsonism emerged in nearly all patients. These findings highlight the need for systematic long-term monitoring extending beyond dystonia control after GPi-DBS.
SN - 0885-3185
SN - 1531-8257
ER -