HPV prevalence and genotype distribution in rare cervical adenocarcinoma subtypes: A 10-year retrospective cohort study from Brazil.
- 1Division of Clinical Research and Technological Development, Brazilian National Cancer Institute, Rio de Janeiro, Brazil.
- 2Division of Pathology, Brazilian National Cancer Institute, Rio de Janeiro, Brazil.
- 3Genetics and Tumor Virology Program, Brazilian National Cancer Institute, Rio de Janeiro, Brazil.
Abstract
This study aimed primarily to determine human papillomavirus prevalence and genotype distribution in rare cervical adenocarcinoma subtypes. Secondary objectives were to evaluate associations between human papillomavirus status, clinicopathological characteristics, and survival outcomes. This retrospective cohort included patients with rare cervical adenocarcinoma subtypes treated at the Brazilian National Cancer Institute between 2011 and 2021. Human papillomavirus deoxyribonucleic acid (DNA) detection and genotyping were performed in histopathological samples. Among 107 patients, the median age at diagnosis was 44.00 years (interquartile range 37.00, 52.50). Tumor samples from 88 patients were available for human papillomavirus DNA analysis, of which 78 (88.64%) were positive. Genotype 16 (69.23%) was the predominant genotype. Non-mucinous adenocarcinomas were associated with poorer overall survival (HR 4.77; 95% CI 1.78, 12.76), whereas human papillomavirus status was not significantly associated with survival outcomes. Human papillomavirus DNA positivity was high among rare cervical adenocarcinoma subtypes. Mucinous variants had significantly better overall survival than non-mucinous subtypes. These findings should be interpreted cautiously given the retrospective, single-center design and small number of human papillomavirus-negative cases, which limited statistical power for survival comparisons.
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BibTeX
@article{vieira2026prevalence,
title = {{HPV prevalence and genotype distribution in rare cervical adenocarcinoma subtypes: A 10-year retrospective cohort study from Brazil.}},
author = {Paula Domith de Oliveira Vieira and Lucas Zanetti de Albuquerque and Aretha Brito Nobre and Juliana Domett Siqueira and Isabele Ávila Small and Marcelo Alves Soares and Andreia Cristina de Melo},
journal = {Preventive medicine reports},
year = {2026},
month = oct,
doi = {10.1016/j.pmedr.2026.103679},
url = {https://europepmc.org/article/MED/42997013},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - HPV prevalence and genotype distribution in rare cervical adenocarcinoma subtypes: A 10-year retrospective cohort study from Brazil.
AU - Paula Domith de Oliveira Vieira
AU - Lucas Zanetti de Albuquerque
AU - Aretha Brito Nobre
AU - Juliana Domett Siqueira
AU - Isabele Ávila Small
AU - Marcelo Alves Soares
AU - Andreia Cristina de Melo
PY - 2026
DA - 2026/10/27
JO - Preventive medicine reports
DO - 10.1016/j.pmedr.2026.103679
UR - https://europepmc.org/article/MED/42997013
AB - This study aimed primarily to determine human papillomavirus prevalence and genotype distribution in rare cervical adenocarcinoma subtypes. Secondary objectives were to evaluate associations between human papillomavirus status, clinicopathological characteristics, and survival outcomes. This retrospective cohort included patients with rare cervical adenocarcinoma subtypes treated at the Brazilian National Cancer Institute between 2011 and 2021. Human papillomavirus deoxyribonucleic acid (DNA) detection and genotyping were performed in histopathological samples. Among 107 patients, the median age at diagnosis was 44.00 years (interquartile range 37.00, 52.50). Tumor samples from 88 patients were available for human papillomavirus DNA analysis, of which 78 (88.64%) were positive. Genotype 16 (69.23%) was the predominant genotype. Non-mucinous adenocarcinomas were associated with poorer overall survival (HR 4.77; 95% CI 1.78, 12.76), whereas human papillomavirus status was not significantly associated with survival outcomes. Human papillomavirus DNA positivity was high among rare cervical adenocarcinoma subtypes. Mucinous variants had significantly better overall survival than non-mucinous subtypes. These findings should be interpreted cautiously given the retrospective, single-center design and small number of human papillomavirus-negative cases, which limited statistical power for survival comparisons.
SN - 2211-3355
ER -