Histopathological Analysis of the Spectrum of Forensic Pathology Lesions Over Two Years From a Tertiary Care…

Abstract

Background and purpose

Medicolegal autopsies provide key insights into the causes of death and disease evolution. This study analyzes the spectrum and frequency of histopathological alterations across major organ systems in medicolegal autopsies over two years at Government Medical College, Thrissur, a tertiary care center in South India.Methods

This descriptive retrospective study included details of 831 autopsy cases. Histopathological findings from cardiovascular, respiratory, hepatobiliary, renal, central nervous, and accessory visceral systems were systematically categorized.Results

Male predominance was observed (594 cases, 71.5%). The 50-59 (21.1%) and 40-49 (19.3%) age groups were most represented. Evaluated left anterior descending (LAD) arteries (N = 388) frequently showed advanced atherosclerosis (AHA type V: 38.9%, 151 cases). In evaluated hearts (N = 628), hypertrophy was present in 19.1% (120 cases) and healed infarcts in 9.6% (60 cases). Evaluated lungs (N = 676) mostly showed congestion with edema (20.1%, 136 cases), isolated congestion (18.8%, 127 cases), and isolated edema (12.9%, 87 cases). Evaluated livers (N = 476) showed congestion (37.4%, 178 cases) and macrovesicular steatosis (21%, 100 cases). Evaluated kidneys (N = 445) demonstrated congestion (40.2%, 179 cases) and chronic kidney disease (18%, 80 cases).Conclusion

Histopathological evaluation revealed a significant subclinical burden of chronic cardiovascular, respiratory, and metabolic conditions. Targeted histopathological examination in forensic autopsies enhances diagnostic precision and informs public health statistics.

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BibTeX RIS

BibTeX

@article{mohan2026histopathological,
  title = {{Histopathological Analysis of the Spectrum of Forensic Pathology Lesions Over Two Years From a Tertiary Care Centre in Kerala: A Descriptive Study}},
  author = {Bhavya P Mohan and Surekha Vijayan and Jilsa Sucheendran and Sheeju P A},
  journal = {Cureus},
  year = {2026},
  month = sep,
  doi = {10.7759/cureus.117165},
  url = {https://europepmc.org/article/PMC/PMC13719108},
  note = {CC BY},
}

RIS

TY  - JOUR
TI  - Histopathological Analysis of the Spectrum of Forensic Pathology Lesions Over Two Years From a Tertiary Care Centre in Kerala: A Descriptive Study
AU  - Bhavya P Mohan
AU  - Surekha Vijayan
AU  - Jilsa Sucheendran
AU  - Sheeju P A
PY  - 2026
DA  - 2026/09/29
JO  - Cureus
DO  - 10.7759/cureus.117165
UR  - https://europepmc.org/article/PMC/PMC13719108
AB  - Background and purpose  Medicolegal autopsies provide key insights into the causes of death and disease evolution. This study analyzes the spectrum and frequency of histopathological alterations across major organ systems in medicolegal autopsies over two years at Government Medical College, Thrissur, a tertiary care center in South India.Methods  This descriptive retrospective study included details of 831 autopsy cases. Histopathological findings from cardiovascular, respiratory, hepatobiliary, renal, central nervous, and accessory visceral systems were systematically categorized.Results  Male predominance was observed (594 cases, 71.5%). The 50-59 (21.1%) and 40-49 (19.3%) age groups were most represented. Evaluated left anterior descending (LAD) arteries (N = 388) frequently showed advanced atherosclerosis (AHA type V: 38.9%, 151 cases). In evaluated hearts (N = 628), hypertrophy was present in 19.1% (120 cases) and healed infarcts in 9.6% (60 cases). Evaluated lungs (N = 676) mostly showed congestion with edema (20.1%, 136 cases), isolated congestion (18.8%, 127 cases), and isolated edema (12.9%, 87 cases). Evaluated livers (N = 476) showed congestion (37.4%, 178 cases) and macrovesicular steatosis (21%, 100 cases). Evaluated kidneys (N = 445) demonstrated congestion (40.2%, 179 cases) and chronic kidney disease (18%, 80 cases).Conclusion  Histopathological evaluation revealed a significant subclinical burden of chronic cardiovascular, respiratory, and metabolic conditions. Targeted histopathological examination in forensic autopsies enhances diagnostic precision and informs public health statistics.
SN  - 2168-8184
ER  -

Abstract

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