Skip to content
DraconiticResearch
Search Sources API
201,683 studies31 sourcesUpdated 23 min ago
Peer-reviewedCC BYScientific Reports

Identification and characterization of the virome in cell-free DNA from peripheral blood of pregnant women in Shaanxi Province, China

  • Yixia Pan1
  • Ruitao Liu2
  • Lijuan He3
  • Xiaomin He3
  • Tong Yang2
  • Ziying Jia2
  • Yanju Jia2
  • Chengbin Yan4
  • Guiqin Bai1
4 affiliations
  1. 1Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xi’an Jiaotong University
  2. 2Gene Joint Laboratory, The First Affiliated Hospital of Xi’an Jiaotong University
  3. 3BGI
  4. 4Shenzhen BGI Medical Laboratory
Read full textPDFDOICite

Abstract

This study characterizes the viral landscape identified within cell-free DNA (cfDNA) from peripheral blood samples of pregnant women in Shaanxi Province, China. Using non-invasive prenatal testing (NIPT) combined with high-throughput sequencing, we analyzed the virome composition in 20,035 maternal plasma samples to determine viral prevalence, regional variations, and potential associations with pregnancy outcomes. Seventy-one distinct viral species were detected, with Human Herpesvirus 7 (HHV-7) being the most common, identified in 9.41% of samples. The overall viral positivity rate among pregnant women in Shaanxi Province was 14.01%, significantly higher than the national average for China. Notable regional disparities in viral prevalence were observed among different cities within the province. Moreover, infection with certain viruses was potentially linked to adverse pregnancy outcomes, including birth defects. Our findings illustrate the distribution and prevalence of viral infections among pregnant women across Shaanxi Province and highlight the possible negative implications of specific viral infections for pregnancy outcomes. These results provide scientific evidence supporting region-specific viral monitoring and targeted public health interventions, particularly in areas exhibiting high infection rates, to minimize and manage risks associated with adverse pregnancy outcomes.

Related

  1. Metagenomic characterization and genetic profiling of hepatic viromes in Marmota himalayana from the Three-River-Source region of Qinghai Province
    Kaiye Ying, Xiaofei Song, Jiaheng Chen +8
    BMC MicrobiologyPeer-reviewedCC BY-NC-ND 4.0Full textEpidemiology & public healthPMC
  2. Prevalence and molecular characterization of hepatitis delta virus infection among hepatitis B virus surface antigen positive students and pregnant women in N'djamena, Chad
    Nalda Debsikréo, Maire Dehainsala, Odan Debsikréo +12
    IJID RegionsPeer-reviewedCC BYEpidemiology & public healthHAL
  3. Olink Platform-Based Identification of Peripheral Blood Biomarkers for irAEs in Advanced NSCLC.
    Zhihan Zhang, Bingchun Chen, Hanmei Jiang +5
    Current oncology (Toronto, Ont.)Peer-reviewedCC BYFull textOncologyEurope PMC
  4. Characterization of diabetic peripheral neuropathy in a high-fat diet mouse model
    Guillaume Rastoldo, Alexis Chirpaz, Sarrah Tréport +9
    PLoS ONEPeer-reviewedCC BY 4.0Full textCell biologyNeuroscienceHALPLOS
  5. Peripheral blood mRNA-based prognostic model for progression to metastatic castration-resistant prostate cancer and identification of SLC6A8 as a glycolysis-promoting biomarker
    Sicong Li, Heling Zhou, Yi Wu +7
    Frontiers in OncologyPeer-reviewedCC BY 4.0Full textOncologyCrossrefEurope PMCPMC

Cite

BibTeXRIS
BibTeX
@article{pan2026identification,
  title = {{Identification and characterization of the virome in cell-free DNA from peripheral blood of pregnant women in Shaanxi Province, China}},
  author = {Yixia Pan and Ruitao Liu and Lijuan He and Xiaomin He and Tong Yang and Ziying Jia and Yanju Jia and Chengbin Yan and Guiqin Bai},
  journal = {Scientific Reports},
  year = {2026},
  month = jul,
  doi = {10.1038/s41598-026-61585-5},
  url = {https://doi.org/10.1038/s41598-026-61585-5},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Identification and characterization of the virome in cell-free DNA from peripheral blood of pregnant women in Shaanxi Province, China
AU  - Yixia Pan
AU  - Ruitao Liu
AU  - Lijuan He
AU  - Xiaomin He
AU  - Tong Yang
AU  - Ziying Jia
AU  - Yanju Jia
AU  - Chengbin Yan
AU  - Guiqin Bai
PY  - 2026
DA  - 2026/07/01
JO  - Scientific Reports
DO  - 10.1038/s41598-026-61585-5
UR  - https://doi.org/10.1038/s41598-026-61585-5
AB  - This study characterizes the viral landscape identified within cell-free DNA (cfDNA) from peripheral blood samples of pregnant women in Shaanxi Province, China. Using non-invasive prenatal testing (NIPT) combined with high-throughput sequencing, we analyzed the virome composition in 20,035 maternal plasma samples to determine viral prevalence, regional variations, and potential associations with pregnancy outcomes. Seventy-one distinct viral species were detected, with Human Herpesvirus 7 (HHV-7) being the most common, identified in 9.41% of samples. The overall viral positivity rate among pregnant women in Shaanxi Province was 14.01%, significantly higher than the national average for China. Notable regional disparities in viral prevalence were observed among different cities within the province. Moreover, infection with certain viruses was potentially linked to adverse pregnancy outcomes, including birth defects. Our findings illustrate the distribution and prevalence of viral infections among pregnant women across Shaanxi Province and highlight the possible negative implications of specific viral infections for pregnancy outcomes. These results provide scientific evidence supporting region-specific viral monitoring and targeted public health interventions, particularly in areas exhibiting high infection rates, to minimize and manage risks associated with adverse pregnancy outcomes.
SN  - 2045-2322
ER  -