Advances in Implant-Based Breast Reconstruction in the Setting of Post-Mastectomy Radiotherapy
- 1Department of Radiation Oncology, Hebei Clinical Research Center for Radiation Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China
Abstract
Background: Breast reconstruction and post-mastectomy radiation therapy (PMRT) have become integral components of comprehensive breast cancer management. The coordination of radiation therapy and reconstruction must balance long-term oncologic safety with optimal aesthetic outcomes.
Objective: This narrative review aims to evaluate and synthesize the latest advancements in the integration of implant-based breast reconstruction and radiotherapy. Specifically, it seeks to clarify the impact of reconstructive timing, material selection, anatomical placement, and advanced radiation techniques on clinical outcomes. The primary endpoint was defined as the incidence of treatment-related complications, and secondary endpoints included long-term aesthetic outcomes and oncologic safety.
Methods: We systematically screened and synthesized the existing literature by searching core databases, including PubMed, Embase, and Web of Science.
Results and Conclusion: Currently, the integration of implant-based breast reconstruction with radiotherapy remains an active area of investigation, with consensus lacking on many key aspects. The integration of implant-based reconstruction and radiotherapy necessitates multidisciplinary collaboration to develop individualized treatment strategies. Future prospective studies are warranted to optimize clinical pathways.
No Level Assigned: This journal requires that authors assign a level of evidence to each submission to which Evidence-Based Medicine rankings are applicable. This excludes Review Articles, Book Reviews, and manuscripts that concern Basic Science, Animal Studies, Cadaver Studies, and Experimental Studies. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266
Supplementary Information: The online version contains supplementary material available at https://doi.org/10.1007/s00266-026-06219-x.
Related
- Long-term implant integrity and complications after risk-reducing mastectomy with immediate implant reconstruction: a retrospective cohort study with prospective ultrasound follow-up at a Swedish university hospital
- Long-term oncological outcomes after nipple-sparing mastectomy and implant-based immediate breast reconstruction in a population-based cohort of breast cancer patients
- Comparison of surgical outcomes, safety, and cosmetic satisfaction between immediate implant-based and transverse rectus abdominis myocutaneous (TRAM) flap breast reconstruction following total mastectomy: a retrospective cohort study
- Thromboembolic and hemorrhagic risks after mastectomy with vs without direct-to-implant reconstruction.
- Implant-Based Versus Autologous Reconstruction After Salvage Mastectomy for Ipsilateral Breast Tumor Recurrence in the Previously Irradiated Breast: A Consecutive Institutional Series and a Proposed Autologous-First Algorithm
BibTeX
@article{wang2026advances,
title = {{Advances in Implant-Based Breast Reconstruction in the Setting of Post-Mastectomy Radiotherapy}},
author = {Qingyu Wang and Bingyue Li and Siyu Chen and Jun Wang},
journal = {Aesthetic Plastic Surgery},
year = {2026},
month = sep,
doi = {10.1007/s00266-026-06219-x},
url = {https://doi.org/10.1007/s00266-026-06219-x},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Advances in Implant-Based Breast Reconstruction in the Setting of Post-Mastectomy Radiotherapy
AU - Qingyu Wang
AU - Bingyue Li
AU - Siyu Chen
AU - Jun Wang
PY - 2026
DA - 2026/09/11
JO - Aesthetic Plastic Surgery
DO - 10.1007/s00266-026-06219-x
UR - https://doi.org/10.1007/s00266-026-06219-x
AB - Background: Breast reconstruction and post-mastectomy radiation therapy (PMRT) have become integral components of comprehensive breast cancer management. The coordination of radiation therapy and reconstruction must balance long-term oncologic safety with optimal aesthetic outcomes. Objective: This narrative review aims to evaluate and synthesize the latest advancements in the integration of implant-based breast reconstruction and radiotherapy. Specifically, it seeks to clarify the impact of reconstructive timing, material selection, anatomical placement, and advanced radiation techniques on clinical outcomes. The primary endpoint was defined as the incidence of treatment-related complications, and secondary endpoints included long-term aesthetic outcomes and oncologic safety. Methods: We systematically screened and synthesized the existing literature by searching core databases, including PubMed, Embase, and Web of Science. Results and Conclusion: Currently, the integration of implant-based breast reconstruction with radiotherapy remains an active area of investigation, with consensus lacking on many key aspects. The integration of implant-based reconstruction and radiotherapy necessitates multidisciplinary collaboration to develop individualized treatment strategies. Future prospective studies are warranted to optimize clinical pathways. No Level Assigned: This journal requires that authors assign a level of evidence to each submission to which Evidence-Based Medicine rankings are applicable. This excludes Review Articles, Book Reviews, and manuscripts that concern Basic Science, Animal Studies, Cadaver Studies, and Experimental Studies. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 Supplementary Information: The online version contains supplementary material available at https://doi.org/10.1007/s00266-026-06219-x.
SN - 0364-216X
SN - 1432-5241
ER -