Using Implementation Science to Improve Guidelines-Based Care to Lower Atherosclerosis Risk Due to Familial Hypercholesterolemia.
5 affiliations
- 1Department of Genomic Health, 100 N. Academy Avenue, Geisinger, Danville, PA, 17822, USA.
- 2Department of Population Health Sciences, Geisinger, Danville, PA, USA.
- 3Geisinger Health Steele Institute for Health Innovation, Geisinger, Danville, PA, USA.
- 4Center for Pharmacy Innovation and Outcomes, Geisinger, Danville, PA, USA.
- 5Department of Genomic Health, 100 N. Academy Avenue, Geisinger, Danville, PA, 17822, USA. [email protected].
Abstract
Purpose of the review
Implementation science, a multi-method research area that integrates input from constituents and content experts, has emerged as an important tool in improving implementation of evidence-based practices. This review summarizes three ongoing implementation studies focused on identification of patients with significantly increased risk for atherosclerotic cardiovascular disease (ASCVD) due to genomic risk such as familial hypercholesterolemia (FH) within a single health system.Recent findings
Despite the existence of evidence-based guidelines for identifying individuals with increased risk for ASCVD from FH and managing their care to reduce risk, substantial care gaps exist in guideline implementation. These include patient understanding of the importance of heart disease prevention, clinician implementation of screening for risk factors, and adherence to recommended treatments. While guidelines often focus on the encounter between a patient and clinician, implementation science enlarges the field of study to encompass factors external to the encounter. These factors include multi-level barriers and facilitators to implementation. By developing strategies to overcome barriers and leverage facilitators, management can be improved for those with FH. Implementation science methods described herein are transferable to other health care settings, with a goal of improving preventive medicine practice and increasing adherence to evidence-based practices for FH.
Related
- Little Evidence of Atherosclerosis in a Middle-aged Japanese Woman with Familial Hypercholesterolemia Carrying PCSK9 (p.Glu32Lys) and ABCG8 (p.Ile419Asn) Variants despite Elevated Lipoprotein (a) Levels
- Familial Hypercholesterolemia Screening: From Pediatric Detection to Life-long Management
- Expectations for Angiopoietin-like 3 Inhibitors Taking Broad Lipid-modifying Effects on the Comprehensive Control of Atherosclerotic Cardiovascular Disease Risk in Patients with Homozygous Familial Hypercholesterolemia
- Significant Associations of Achilles Tendon Thickness With Atherosclerotic Diseases and Atherosclerotic Risk Factors in Non-Familial Hypercholesterolemia Patients: A Cross-Sectional Study
- Effectiveness of LDL Apheresis Techniques for Reducing LDL‐C in Familial Hypercholesterolemia: A Systematic Review and Meta‐Analysis
BibTeX
@article{hallquist2026using,
title = {{Using Implementation Science to Improve Guidelines-Based Care to Lower Atherosclerosis Risk Due to Familial Hypercholesterolemia.}},
author = {Miranda L G Hallquist and Andrew Brangan and Dylan Cawley and Jazmine L Gabriel and Muki Kunnmann and Kevin Ly and Ana Morales and Katrina Romagnoli and Juliann M Savatt and Nicole L Walters and Samuel S Gidding},
journal = {Current atherosclerosis reports},
year = {2026},
month = oct,
doi = {10.1007/s11883-026-01477-1},
url = {https://europepmc.org/article/MED/42925367},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Using Implementation Science to Improve Guidelines-Based Care to Lower Atherosclerosis Risk Due to Familial Hypercholesterolemia.
AU - Miranda L G Hallquist
AU - Andrew Brangan
AU - Dylan Cawley
AU - Jazmine L Gabriel
AU - Muki Kunnmann
AU - Kevin Ly
AU - Ana Morales
AU - Katrina Romagnoli
AU - Juliann M Savatt
AU - Nicole L Walters
AU - Samuel S Gidding
PY - 2026
DA - 2026/10/24
JO - Current atherosclerosis reports
DO - 10.1007/s11883-026-01477-1
UR - https://europepmc.org/article/MED/42925367
AB - Purpose of the review Implementation science, a multi-method research area that integrates input from constituents and content experts, has emerged as an important tool in improving implementation of evidence-based practices. This review summarizes three ongoing implementation studies focused on identification of patients with significantly increased risk for atherosclerotic cardiovascular disease (ASCVD) due to genomic risk such as familial hypercholesterolemia (FH) within a single health system.Recent findings Despite the existence of evidence-based guidelines for identifying individuals with increased risk for ASCVD from FH and managing their care to reduce risk, substantial care gaps exist in guideline implementation. These include patient understanding of the importance of heart disease prevention, clinician implementation of screening for risk factors, and adherence to recommended treatments. While guidelines often focus on the encounter between a patient and clinician, implementation science enlarges the field of study to encompass factors external to the encounter. These factors include multi-level barriers and facilitators to implementation. By developing strategies to overcome barriers and leverage facilitators, management can be improved for those with FH. Implementation science methods described herein are transferable to other health care settings, with a goal of improving preventive medicine practice and increasing adherence to evidence-based practices for FH.
SN - 1523-3804
SN - 1534-6242
ER -