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Peer-reviewedCC BYCells

Homoharringtonine Suppresses Prostate Cancer Progression Through Modulation of the TNF/NF-κB and MAPK Signaling Pathways

  • Yuzhong Chen1,2
  • Sisi Huang1,2
  • Dongyan Huang1,2
  • Yangtao Jin1
  • Congcong Shao1,2
  • Xin Su1,2
  • Rongfu Yang1,2
  • Juan Jiang1
  • Jianhui Wu1,2
  1. 1NHC Key Lab of Reproduction Regulation, Shanghai Engineering Research Center of Reproductive Health Drug and Devices, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Pharmacy School of Pharmaceutical Sciences Fudan University, Shanghai 200237, China
  2. 2Department of Pharmacology & Toxicology, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai 200032, China
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Abstract

Prostate cancer (PCa) represents one of the leading causes of cancer-related mortality among men. The efficacy of its treatment is often compromised by chemotherapeutic toxicity and multidrug resistance, underscoring the urgent need to develop efficient and low-toxicity alternative therapeutic strategies. Homoharringtonine (HHT), a bioactive compound, has demonstrated clinical anticancer efficacy in hematologic malignancies. However, its role and underlying mechanisms in prostate cancer remain largely unclear. This study provides evidence that HHT suppresses prostate cancer cell proliferation and promotes cell cycle arrest by modulating the TNF/NF-κB and MAPK signaling pathways, indicating its potential as a promising natural drug candidate for PCa treatment.

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Cite

BibTeXRIS
BibTeX
@article{chen2026homoharringtonine,
  title = {{Homoharringtonine Suppresses Prostate Cancer Progression Through Modulation of the TNF/NF-κB and MAPK Signaling Pathways}},
  author = {Yuzhong Chen and Sisi Huang and Dongyan Huang and Yangtao Jin and Congcong Shao and Xin Su and Rongfu Yang and Juan Jiang and Jianhui Wu},
  journal = {Cells},
  year = {2026},
  month = sep,
  doi = {10.3390/cells15191788},
  url = {https://europepmc.org/article/PMC/PMC13664184},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Homoharringtonine Suppresses Prostate Cancer Progression Through Modulation of the TNF/NF-κB and MAPK Signaling Pathways
AU  - Yuzhong Chen
AU  - Sisi Huang
AU  - Dongyan Huang
AU  - Yangtao Jin
AU  - Congcong Shao
AU  - Xin Su
AU  - Rongfu Yang
AU  - Juan Jiang
AU  - Jianhui Wu
PY  - 2026
DA  - 2026/09/30
JO  - Cells
DO  - 10.3390/cells15191788
UR  - https://europepmc.org/article/PMC/PMC13664184
AB  - Prostate cancer (PCa) represents one of the leading causes of cancer-related mortality among men. The efficacy of its treatment is often compromised by chemotherapeutic toxicity and multidrug resistance, underscoring the urgent need to develop efficient and low-toxicity alternative therapeutic strategies. Homoharringtonine (HHT), a bioactive compound, has demonstrated clinical anticancer efficacy in hematologic malignancies. However, its role and underlying mechanisms in prostate cancer remain largely unclear. This study provides evidence that HHT suppresses prostate cancer cell proliferation and promotes cell cycle arrest by modulating the TNF/NF-κB and MAPK signaling pathways, indicating its potential as a promising natural drug candidate for PCa treatment.
SN  - 2073-4409
ER  -