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Peer-reviewedCC BY 4.0Frontiers in Oncology

COL1A2 expression is associated with prognosis, stromal remodeling, and predicted immunotherapy response in gastric cancer

  • Fengming Luan
  • Guofeng Chen
  • Ke Chen
  • Chaoyang Zhang
  • Xiaoman He
  • Jian Chen
  • Shenbin Xu
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Abstract

BackgroundCOL1A2 encodes type I collagen alpha2 chain, a stromal component in gastric cancer (GC); its prognostic value, cellular origin, and immune microenvironment relation remain unclear.MethodsWe analyzed TCGA-STAD, GSE63089, and ACRG GSE62254. Associations between COL1A2 abundance and overall survival (OS), clinicopathology, pathways, and tumor microenvironment were assessed. High/low groups by median expression. Two Cox models used pathological stage or separate T/N/M. Immunotherapy response predicted via TIDE and IPS. WGCNA, PPI, and LASSO with five ECM genes, ten-fold cross-validation and 200 repeats, were applied. qPCR and Western blot measured mRNA and protein in seven paired tissues.ResultsCOL1A2 was higher in GC and linked to poorer OS, but time-dependent AUCs were 0.60, 0.65, 0.66. In ACRG, OS association was not significant (HR 1.83, P = 0.085). Per SD increase, adjusted HR was 1.21 (stage model, P = 0.036) and 1.14 (T/N/M model, P = 0.171). C-index gains were only 0.006 and 0.003. Higher abundance correlated with stroma-rich microenvironment and M2 macrophage infiltration. TIDE/IPS predicted lower ICI response probability. LASSO selected SPARC, ELN, and BGN stably. Tumor tissues showed higher mRNA and protein.ConclusionsCOL1A2 associates with poor prognosis, stromal remodeling, and predicted immunotherapy response, but its prognostic effect varies between models and discrimination improvement is small.

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Cite

BibTeXRIS
BibTeX
@article{luan2026col1a2,
  title = {{COL1A2 expression is associated with prognosis, stromal remodeling, and predicted immunotherapy response in gastric cancer}},
  author = {Fengming Luan and Guofeng Chen and Ke Chen and Chaoyang Zhang and Xiaoman He and Jian Chen and Shenbin Xu},
  journal = {Frontiers in Oncology},
  year = {2026},
  month = oct,
  doi = {10.3389/fonc.2026.1912517},
  url = {https://www.frontiersin.org/articles/10.3389/fonc.2026.1912517},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - COL1A2 expression is associated with prognosis, stromal remodeling, and predicted immunotherapy response in gastric cancer
AU  - Fengming Luan
AU  - Guofeng Chen
AU  - Ke Chen
AU  - Chaoyang Zhang
AU  - Xiaoman He
AU  - Jian Chen
AU  - Shenbin Xu
PY  - 2026
DA  - 2026/10/30
JO  - Frontiers in Oncology
DO  - 10.3389/fonc.2026.1912517
UR  - https://www.frontiersin.org/articles/10.3389/fonc.2026.1912517
AB  - BackgroundCOL1A2 encodes type I collagen alpha2 chain, a stromal component in gastric cancer (GC); its prognostic value, cellular origin, and immune microenvironment relation remain unclear.MethodsWe analyzed TCGA-STAD, GSE63089, and ACRG GSE62254. Associations between COL1A2 abundance and overall survival (OS), clinicopathology, pathways, and tumor microenvironment were assessed. High/low groups by median expression. Two Cox models used pathological stage or separate T/N/M. Immunotherapy response predicted via TIDE and IPS. WGCNA, PPI, and LASSO with five ECM genes, ten-fold cross-validation and 200 repeats, were applied. qPCR and Western blot measured mRNA and protein in seven paired tissues.ResultsCOL1A2 was higher in GC and linked to poorer OS, but time-dependent AUCs were 0.60, 0.65, 0.66. In ACRG, OS association was not significant (HR 1.83, P = 0.085). Per SD increase, adjusted HR was 1.21 (stage model, P = 0.036) and 1.14 (T/N/M model, P = 0.171). C-index gains were only 0.006 and 0.003. Higher abundance correlated with stroma-rich microenvironment and M2 macrophage infiltration. TIDE/IPS predicted lower ICI response probability. LASSO selected SPARC, ELN, and BGN stably. Tumor tissues showed higher mRNA and protein.ConclusionsCOL1A2 associates with poor prognosis, stromal remodeling, and predicted immunotherapy response, but its prognostic effect varies between models and discrimination improvement is small.
SN  - 2234-943X
ER  -