PreprintCC BY-NCbioRxiv
Multipotent tail bud cells originated with the chordate common ancestor
- 1Kyoto University
Abstract
In vertebrate embryos, the tail bud region generates the neural tube, the notochord, and somites in the posterior part of the body, including the post-anal tail. Here, we traced the fate of tail bud cells during embryogenesis in the cephalochordate, amphioxus, the earliest diverging lineage of extant chordates, and showed that in amphioxus as well, these cells contribute to the neural tube, the notochord, and somites. Our work provides direct evidence to support the hypothesis that ancestral chordates possessed tail bud cells capable of producing both neural and mesodermal derivatives, illuminating the evolutionary origin of posterior body development in chordates.
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BibTeX
@misc{ishida2026multipotent,
title = {{Multipotent tail bud cells originated with the chordate common ancestor}},
author = {T. Ishida and W.-C. Chu and J.-K. Yu and Y. Satou},
howpublished = {bioRxiv},
year = {2026},
month = oct,
doi = {10.64898/2026.10.25.761592},
url = {https://www.biorxiv.org/content/10.64898/2026.10.25.761592v1},
note = {CC BY-NC},
}
RIS
TY - UNPB
TI - Multipotent tail bud cells originated with the chordate common ancestor
AU - T. Ishida
AU - W.-C. Chu
AU - J.-K. Yu
AU - Y. Satou
PY - 2026
DA - 2026/10/25
PB - bioRxiv
DO - 10.64898/2026.10.25.761592
UR - https://www.biorxiv.org/content/10.64898/2026.10.25.761592v1
AB - In vertebrate embryos, the tail bud region generates the neural tube, the notochord, and somites in the posterior part of the body, including the post-anal tail. Here, we traced the fate of tail bud cells during embryogenesis in the cephalochordate, amphioxus, the earliest diverging lineage of extant chordates, and showed that in amphioxus as well, these cells contribute to the neural tube, the notochord, and somites. Our work provides direct evidence to support the hypothesis that ancestral chordates possessed tail bud cells capable of producing both neural and mesodermal derivatives, illuminating the evolutionary origin of posterior body development in chordates.
ER -